volume 93, issue 0, P3-P-360 2020
DOI: 10.1254/jpssuppl.93.0_3-p-360
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Abstract: The bioactive lipid sphingosine 1-phosphate (S1P) binds to five known G protein-coupled receptors, S1P 1-5 , and acts as a second messenger during cell signaling. Among them FTY720 targeting S1P 1 is used for immunosuppressive agent for the treatment of autoimmune disease. However, FTY720 acts through multiple S1P receptors, the mechanism of action through one or more of these receptors may account for its side effects. In 2011, the X-ray crystal structure of antagonist-bound inactive state S1P 1 was solved, b…

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