Structural analysis and characterization of new small serum proteins from the serum of a venomous snake (<i>Gloydius blomhoffii</i>)

Shioi, Narumi; Deshimaru, Masanobu; Terada, Shigeyuki

doi:10.1080/09168451.2014.890030

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…Mamushi venom consists of a variety of multiple enzymes that work as hemolytic toxins, including phospholipase A2, neurotoxins, and an alpha-toxin/a beta-toxin, that increase vascular permeability. Moreover, the venom contains arginine ester dehydrogenase that causes rhabdomyolysis, endopeptidase/bleeding factor (HR1 and HR2) that causes platelet aggregation, and L-amino acid oxidase 3 , 4 , 5 , 6 , 7 , 8 ) .…”

Section: Introductionmentioning

confidence: 99%

Prognostic indicators among laboratory data on arrival to assess the severity of mamushi bites

et al. 2019

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Objective: This study aimed to retrospectively determine which laboratory data on arrival for patients with mamushi bites was useful to predict the severity of mamushi bites.Materials and Methods: The subjects were divided into the following two groups: the mild group included subjects with mamushi bites Grades I and II, while the severe group included subjects with mamushi bites Grades III, IV, and V. The subjects’ variables were compared between the two groups.Results: There were no significant differences between the two groups regarding the levels of hematocrit, total protein, alanine aminotransferase, aspartate aminotransferase, creatinine phosphokinase, blood urea nitrogen, creatinine, and international normalized ratio of prothrombin time on arrival. Moreover, white blood cell count and platelet count on arrival in the mild group were significantly lower than those in the severe group. Furthermore, activated partial thromboplastin time on arrival was significantly higher in the mild group than in the severe group. Multivariate analysis using white blood cell count and platelet count and level of activated partial thromboplastin time revealed the following significant prognostic indicators of severity of mamushi bites: white blood cell count (Log Worth, 2.1; p<0.01) and platelet count (Log Worth, 1.6; p<0.05).Conclusion: White blood cell count and platelet count on arrival of patients with mamushi bites are considered significant prognostic indicators in determining the severity of mamushi bites.

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Section: Introductionmentioning

confidence: 99%

Prognostic indicators among laboratory data on arrival to assess the severity of mamushi bites

et al. 2019

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“…Even though the previously mentioned C -terminal deletion did not affect cMSF anti-hemorrhagic activity, the authors demonstrated that cMSF has a lower thermal stability limit (60 °C) when compared to HSF (100 °C) [ 56 ]. Shioi and colleagues also managed to purify SSPs from the serum of the Japanese mamushi that, as above discussed for HSF, interacted with jMSF in a yet to be described mechanism [ 57 ].…”

Section: Biochemical Backgroundmentioning

confidence: 99%

Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Bastos

Gomes-Neto

Perales

et al. 2016

Toxins

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The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom. During the past 40 years, SVMPIs have been isolated mainly from the sera of resistant animals, and characterized to different extents. They are acidic oligomeric glycoproteins that remain biologically active over a wide range of pH and temperature values. Based on primary structure determination, mammalian plasmatic SVMPIs are classified as members of the immunoglobulin (Ig) supergene protein family, while the one isolated from muscle belongs to the ficolin/opsonin P35 family. On the other hand, SVMPIs from snake plasma have been placed in the cystatin superfamily. These natural antitoxins constitute the first line of defense against snake venoms, inhibiting the catalytic activities of snake venom metalloendopeptidases through the establishment of high-affinity, non-covalent interactions. This review presents a historical account of the field of natural resistance, summarizing its main discoveries and current challenges, which are mostly related to the limitations that preclude three-dimensional structural determinations of these inhibitors using “gold-standard” methods; perspectives on how to circumvent such limitations are presented. Potential applications of these SVMPIs in medicine are also highlighted.

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Adaptation and diversification of venomous snake proteins

Aoki-Shioi

2019

Nucleus

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Structural analysis and characterization of new small serum proteins from the serum of a venomous snake (Gloydius blomhoffii)

Cited by 9 publications

References 37 publications

Prognostic indicators among laboratory data on arrival to assess the severity of mamushi bites

Prognostic indicators among laboratory data on arrival to assess the severity of mamushi bites

Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Adaptation and diversification of venomous snake proteins

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