2020 DOI: 10.20944/preprints202009.0185.v1 View full text Preprint
Munkhzaya Byambaragchaa, Dong-An Kim, Dae-Jung Kim, Sun-Mee Hong, Myung-Hwa Kang, Kwan-Sik Min

Abstract: We analyzed signal transduction of three constitutively activating mutants (M410T, L469R, and D590Y) and two inactivating mutants (D417N and Y558F) of the eel luteinizing hormone receptor (eel LHR), known to occur in human LHR. The objective of this study was to assess the functional effects of these mutations in signal transduction and cell surface loss of receptor. Mutant receptors were transiently expressed in Chinese hamster ovary (CHO-K1) cells. Eel LH-stimulated accumulation of cyclic adenosine monophosp…

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