2004
DOI: 10.1161/01.cir.0000147780.30124.cf
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Abstract: Background-After myocardial infarction (MI), bone marrow-derived cells (BMDCs) are found within the myocardium.The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell-derived factor-1␣ (SDF-1) in this process. Methods and Results-MI produced in mice by coronary ligation induced SDF-1 mRNA and protein expression in the infarct and border zone and decreased serum SDF-1 levels. By quantitative polymerase chain reaction, 48 hours after intravenous infusion … Show more

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Cited by 738 publications
(591 citation statements)
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“…These mobilized stem cells subsequently differentiate to adopt cardiac phenotype [20,21]. There are reports defining a possible role for SDF-1α in post MI recruitment of extra-cardiac stem cells [6,22]. Nevertheless, the intrinsic up-regulated expression of SDF-1α in response to MI is insufficient and short-lived.…”
Section: Discussionmentioning
confidence: 99%
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“…These mobilized stem cells subsequently differentiate to adopt cardiac phenotype [20,21]. There are reports defining a possible role for SDF-1α in post MI recruitment of extra-cardiac stem cells [6,22]. Nevertheless, the intrinsic up-regulated expression of SDF-1α in response to MI is insufficient and short-lived.…”
Section: Discussionmentioning
confidence: 99%
“…SDF-1α specifically interacts with the CXCR4 receptor and orchestrates the mobilization and homing of hematopoietic stem cells from bone marrow (BM) to the ischemic heart [3][4][5][6]. Physiologically, BM harbors a heterogenous population of cells positive for CXCR4 receptor.…”
Section: Introductionmentioning
confidence: 99%
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“…HSC and other nonhematopoietic stem cells are actively chemoattracted by factors secreted by BM stroma cells and osteoblasts (e.g., stromal derived factor-1 [SDF-1] and hepatocyte growth factor [HGF]) and colonize marrow by the end of the second and the beginning of the third trimester of gestation (Kmiecik et al, 1992;Ma et al, 1998;Nagasawa, 2000;Taichman et al, 2001). Accumulating evidence suggests that these nonhematopoietic stem cells residing in the BM play some role in the homeostasis/turnover of peripheral tissues and if needed could be released/mobilized from the BM into circulation during tissue injury and stress, thus facilitating the regeneration of damaged organs (LaBarge and Blau, 2002;Kale et al, 2003;Kollet et al, 2003;Abbott et al, 2004;Kucia et al, 2004Kucia et al, , 2006cWojakowski et al, 2004;Long et al, 2005;Gomperts et al, 2006). It is also possible that, in steady state conditions, they shuttle at very low level between BM and stem cell niches in peripheral organs/tissues.…”
Section: Introductionmentioning
confidence: 99%