Stromal cell‐derived factor‐1 regulates the secretion of interleukin‐1β in the temporomandibular joint of rats with synovial inflammation

Dong, Qi; Sun, Song; Han, Liang; Wang, Qiang; Kong, Jianyi; Zhang, Yujun; Wang, Ronglin; Chen, Yan; Ji, Ping

doi:10.1111/jop.13040

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…This initially verified our speculation. The components of synovial fluid are mainly derived from synovial tissue, which includes various inflammatory irritants that contribute to cartilage destruction (Wang et al, 2015;Qi et al, 2020). In recent years, attention has begun to be paid to the importance of synovium in the etiology of OA, and some studies have even proposed synovitis as an independent risk factor for OA (Felson et al, 2016;MacFarlane et al, 2019;Wang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway

Li,

Peng,

Yan

et al. 2023

Front. Pharmacol.

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Background: The temporomandibular joint is often afflicted by osteoarthritis (TMJOA), causing pain and dysfunction, which is particularly prevalent in the elderly population. IL-37 is effective in avoiding excessive inflammatory damage to the organism. This article investigates the role and mechanism of intracellular IL-37 in TMJOA.Methods: Enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, Western blotting, Senescence-associated β-galactosidase staining, immunofluorescence, and lentivirus were performed to elucidate the underlying mechanism.Results: The results confirmed that IL-37 in synovial cells decreased with aging. Inflammatory stimulus elevated intracellular IL-37 in synoviocytes, while lentiviral knockdown of IL-37 resulted in more inflammatory factor production. Dynamic changes of IL-37 were observed in the nucleus and supernatant. In addition, Caspease-1 inhibitor hindered intracellular IL-37 maturation, and Smad3 inhibitor caused the loss of nuclear translocation of mature IL-37. Transfection of synovial cells with IL-37-expressing lentivirus resulted in relief not only of synovitis but also of the cartilage damage and inflammation caused by synovitis.Conclusion: This study provides new insights into the intracellular anti-inflammatory mechanism of IL-37. It also confirms that IL-37 decreases with cellular senescence and that increasing intracellular IL-37 can effectively treat synovitis and synovitis-induced inflammatory damage to cartilage.

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Section: Discussionmentioning

confidence: 99%

IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway

Li,

Peng,

Yan

et al. 2023

Front. Pharmacol.

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“…Several associations have been observed between internal derangements of the TMJ and polymorphism in genes implicated in various biological processes, including degradation of extracellular matrix components (matrix metalloproteinase 1 (MMP1)) (11), sensitivity to pain (catechol-O-methyltransferase (COMT)) (13), anti-inflammation (interleukin 10 (IL10)) ( 20) and proinflammation (interleukin 6 (IL6), interleukin 1 beta (IL1β) and tumor necrosis factor alpha (TNFα)) (12,21,22).…”

Section: Role Of Genetics In Tmjdmentioning

confidence: 99%

“…Among these mechanisms, genetics has surfaced as a promising avenue leading to deeper comprehension of TMJD, a pivotal step toward tailoring personalized therapeutic interventions in the future. The published findings of studies exploring the role of genetic polymorphisms may serve as a foundation for elucidating the genetic background of TMJD (4,(11)(12)(13)(14)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

Role of female reproductive hormones and genetics in temporomandibular joint disorders

Kalmanova,

Halasa,

Slobodnikova

et al. 2024

BLL

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“… 27 Moreover, SDF-1, Dkk-1, and p38 MAPK are also involved in generating and processing TMJ OA. 28 , 29 , 30 …”

Section: Pathological Changes In Temporomandibular Joint Osteoarthritismentioning

confidence: 99%

Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis

Zhang¹,

Xing-tong²,

Zhang³

et al. 2023

Journal of Dental Sciences

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Stromal cell‐derived factor‐1 regulates the secretion of interleukin‐1β in the temporomandibular joint of rats with synovial inflammation

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 25 publications

IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway

IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway

Role of female reproductive hormones and genetics in temporomandibular joint disorders

Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis

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