Stroke subtypes among Chinese living in Hong Kong

Kay, R.; Woo, Jean; Kreel, L.; Wong, Hau Yan; Teoh, R.; Nicholls, M. Gary

doi:10.1212/wnl.42.5.985

Cited by 73 publications

(52 citation statements)

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“…[7][8][9][10][11][12][13][14][15][16] Previous studies in China, Hong Kong, Taiwan, and Japan generally found that 23% to 52.2% of strokes were hemorrhagic, [3][4][5][6][21][22][23][24][25] in contrast to only 9% to 18% in whites. [7][8][9][10][11][12][13][14][15][16] In the present study, 29.6% of stroke cases overall in 2000 were hemorrhagic in Chinese populations, which supported the above idea that an ethnic difference existed between Eastern and Western populations.…”

Section: Stroke Subtypes In Chinese Populations Compared With Westernmentioning

confidence: 99%

Proportion of Different Subtypes of Stroke in China

Zhang

Yang

Hong

et al. 2003

Stroke

313

193

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Background and Purpose-The goal of this article is to clarify the proportion of stroke subtypes in China, where stoke is the most common cause of death. Methods-A total of 16 031 first-ever strokes in subjects Ն25 years of age were identified in 1991 to 2000 from 17 Chinese populations through a community-based cardiovascular disease surveillance program in the China Multicenter Collaborative Study of Cardiovascular Epidemiology. World Health Organization diagnosis criteria were used for classification of stroke subtypes. Results-CT scan rate of stroke cases reached a satisfactorily high level only after 1996 in the study populations. In 8268 first-ever stroke events from 10 populations with CT scan rate Ͼ75% in 1996 to 2000, 1.8% were subarachnoid hemorrhage, 27.5% were intracerebral hemorrhage, 62.4% were cerebral infarction, and 8.3% were undetermined stroke. The proportion of intracerebral hemorrhage varied from 17.1% to 39.4% and that for cerebral infarction varied from 45.5% to 75.9% from population to population. The ratio of ischemic to hemorrhagic stroke ranged from 1.1 to 3.9 and averaged 2.0). The 28-day fatality rate was 33.3% for subarachnoid hemorrhage, 49.4% for intracerebral hemorrhage, 16.9% for cerebral infarction, and 64.6% for undetermined stroke. Conclusions-In our study, ischemic stroke was more frequent and its proportion was higher than hemorrhagic stroke in Chinese populations. Although hemorrhagic stroke was more frequent in Chinese than in Western populations, the variation in the proportion of stroke subtypes among Chinese populations could be as large as or larger than that between

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Section: Stroke Subtypes In Chinese Populations Compared With Westernmentioning

confidence: 99%

Proportion of Different Subtypes of Stroke in China

Zhang

Yang

Hong

et al. 2003

Stroke

313

193

View full text Add to dashboard Cite

show abstract

“…For example, in the early 1990s, age-adjusted mortality rates (per 100,000) of 56 and 129 were reported for CHD and stroke in China, whereas the corresponding rates for the US Caucasian population were 124 and 28, and those for the UK Caucasian population were 284 and 51 respectively [3]. In addition to differences in prevalence rates, the distribution of arterial atherosclerotic lesions also varies between Oriental and Caucasian populations [4,5]. Furthermore, intracerebral haemorrhage has been reported to be two to three times more frequent in Chinese populations than in Caucasian populations, accounting for 20 to 30% of strokes [5].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to differences in prevalence rates, the distribution of arterial atherosclerotic lesions also varies between Oriental and Caucasian populations [4,5]. Furthermore, intracerebral haemorrhage has been reported to be two to three times more frequent in Chinese populations than in Caucasian populations, accounting for 20 to 30% of strokes [5].…”

Section: Introductionmentioning

confidence: 99%

Albuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patients

et al. 2004

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Aims/hypothesis. Albuminuria has been reported to be a marker of cardiovascular risk factors and disease morbidity and mortality, but its relationship with intracerebral atherosclerotic disease is less clear. The aim of this study was to investigate the association between albuminuria and intracranial and extracranial vascular involvement in Chinese Type 2 diabetic patients. Methods. The anthropometric and fasting biochemical measurements of 966 Type 2 diabetic patients with normoalbuminuria (55.6%), microalbuminuria (27.7%) or macroalbuminuria (16.7%) were compared. The prevalence of microvascular and macrovascular disease and middle cerebral artery (MCA) stenosis, measured by transcranial Doppler ultrasound, were also compared between the groups. Results. Albuminuria was closely associated with a range of adverse parameters, including high BP, dyslipidaemia, smoking and adiposity (all p<0.01). The prevalence of microvascular disease (retinopathy p<0.001) and macrovascular disease (peripheral vascular disease p=0.012, myocardial infarction, p=0.004, MCA stenosis p<0.001) increased significantly with increasing levels of albuminuria. Albuminuria was also found to be an independent predictor of microvascular and macrovascular disease. Conclusions/interpretation. Albuminuria was an independent predictor of increasing levels of vascular risk factors and microvascular and macrovascular disease in this group of Type 2 diabetic patients, and a possible role for albuminuria as a marker of intracranial cerebrovascular disease should be further investigated.

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“…Intracerebral hemorrhage has been reported to be two to three times more frequent in Chinese than in Caucasian populations, accounting for 20 -30% of strokes (6). In 114 nonselected autopsy subjects from Hong Kong, intracranial stenosis was found to be more severe than extracranial stenosis (7).…”

mentioning

confidence: 99%

Increasing Severity of Cardiovascular Risk Factors With Increasing Middle Cerebral Artery Stenotic Involvement in Type 2 Diabetic Chinese Patients With Asymptomatic Cerebrovascular Disease

et al. 2004

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OBJECTIVE -To identify determinants associated with increasing severity of middle cerebral artery (MCA) stenosis in asymptomatic Chinese type 2 diabetic patients with and without MCA stenosis determined using transcranial Doppler. Conventional risk factors contribute to the pathogenesis of ischemic stroke, and differences in the pattern of these may explain the heterogeneity of disease presentation in different populations. In Chinese patients, MCA stenosis is the most commonly identified intracranial vascular lesion. RESEARCH DESIGN AND METHODS -Anthropometric and fasting biochemicalparameters were compared between type 2 diabetic patients with MCA stenosis in one (n ϭ 185) or both (n ϭ 200) vessels and 1,492 type 2 diabetic patients without evidence of stenosis.RESULTS -Increasing MCA stenotic vascular involvement was associated with significantly increasing age, duration of diabetes, systolic blood pressure, and LDL cholesterol, but with lower glucose levels. There was also an increased prevalence of hypertension, dyslipidemia, and use of blood pressure-and glucose-lowering agents in the patients with MCA stenosis. Concomitant significant increases in the prevalence of peripheral vascular disease and retinopathy were also observed in the patients with MCA stenosis.CONCLUSIONS -Transcranial Doppler examination identified stenosis in one or both MCAs in over one-fifth of the Chinese type 2 diabetic subjects without symptoms of cerebrovascular disease. A number of conventional cardiovascular risk factors were closely associated with MCA stenosis. This technique may allow the identification of a particularly high-risk group, and further studies are required to determine whether asymptomatic MCA stenosis is predictive of primary cerebrovascular events and whether intensive treatment of risk factors would reduce the risk.

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Stroke subtypes among Chinese living in Hong Kong

Cited by 73 publications

References 0 publications

Proportion of Different Subtypes of Stroke in China

Proportion of Different Subtypes of Stroke in China

Albuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patients

Increasing Severity of Cardiovascular Risk Factors With Increasing Middle Cerebral Artery Stenotic Involvement in Type 2 Diabetic Chinese Patients With Asymptomatic Cerebrovascular Disease

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