Stroke recurrence among Filipino patients taking aspirin for first‐ever non‐cardioembolic ischemic stroke

Abstract

Background: Stroke is the second leading cause of death in the Philippines. There is no Filipino data on stroke recurrence rates. Aim: The present study aimed to determine the risk of recurrence for stroke, myocardial infarction and death among Filipino patients taking varying doses of aspirin with first-ever non-cardioembolic strokes, and identify factors associated with stroke recurrence. Methods: Patients aged 40-79 years with non-cardioembolic ischemic stroke within 30 days from symptom onset who were taking varying doses of aspirin were included, and followed up monthly for the occurrence of recurrent stroke, myocardial infarction and/or death. Demographic and clinical data were collected at baseline and during each follow-up assessment. Results: A total of 262 patients with first-ever, non-cardioembolic stroke were included. The mean age was 56 AE 9 years. The mean follow-up was 263.4 days. The cumulative survival rate for recurrent stroke was 92.1% at 1 year and 87.6% at 2 years. The cumulative survival rate for combined outcome of recurrent stroke, myocardial infarction, and/ or death was 91.1% at 1 year and 82.1% at 2 years. Stroke recurrence was associated with the lack of effort to modify diet. Conclusions: Among Filipino patients taking aspirin for first-ever, non-cardioembolic ischemic stroke, the risk for stroke recurrence was 7.9% in the first year and 12.4% in the second year. The risk for combined stroke, myocardial infarction, and death was 8.9% in the first year and 17.9% in the second year. The lack of effort to modify diet was associated with stroke recurrence.

Intracranial Arterial Stenosis Among Filipino Ischemic Stroke Patients: A Single Center Study

“…29 Additionally, in 262 first-ever noncardioembolic ischemic stroke, the rate of stroke recurrence approximates what we have reported. 30 The cumulative survival rate for recurrent stroke is 92.1% in the first year and 87.6% in the second year showing a recurrent rate of 7.9% and 12.4%, respectively, in this 2-year observational study. Excellent compliance to medication and changes in lifestyle may have contributed to the low recurrence seen in this study.…”

Multicentre collection of uniform data on patients hospitalised for transient ischaemic attack or stroke in the Philippines: the Philippine Neurological Association One Database-Stroke (PNA1DB-Stroke) protocol

“…In an analysis of 1025 stroke patients from 11 hospitals in the Philippines, patients who were admitted to stroke units had better outcomes than those admitted to the general neurology wards 10. For secondary prevention, a multicentre study on 262 Filipino patients taking aspirin for first-ever ischaemic stroke showed that the risk for stroke recurrence was 7.9% in the first year and 12.4% in the second year, while the risk for combined stroke, myocardial infarction and death was 8.9% in the first year and 17.9% in the second year 11. How these patients with recurrent events are managed is unclear.…”