The validity of the Coleman mechanism, which automatically tunes the fundamental constants, is examined in two-dimensional and four-dimensional quantum gravity theories. First, we consider two-dimensional Euclidean quantum gravity on orientable closed manifolds coupled to conformal matter of central charge c ≤ 1. The proper time Hamiltonian of this system is known to be written as a field theory of noncritical strings, which can also be viewed as a third quantization in two dimensions. By directly counting the number of random surfaces with various topologies, we find that the contribution of the baby universes is too small to realize the Coleman mechanism. Next, we consider four-dimensional Lorentzian gravity. Based on the difference between the creation of the mother universe from nothing and the annihilation of the mother universe into nothing, we introduce a non-Hermitian effective Hamiltonian for the multiverse. We show that Coleman’s idea is satisfied in this model and that the cosmological constant is tuned to be nearly zero. Potential implications for phenomenology are also discussed.