Striatal dopamine uptake and olfactory dysfunction in patients with early Parkinson's disease

Oh, Yoon‐Sang; Kim, Joong‐Seok; Hwang, Eo‐Jin; Lyoo, Chul Hyoung

doi:10.1016/j.parkreldis.2018.06.022

Cited by 39 publications

(20 citation statements)

References 25 publications

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“…Investigations on DAT involving 18 F-FP-CIT PET in patients with PD revealed that the decline in DAT binding in the caudate nucleus may be linked to olfactory disorders in patients with PD. [ 35 ] This finding is consistent with that of a 123 I-FP-CIT SPECT study, [ 36 ] and they found that mice lacking DAT are unable to distinguish between habitual smell and new odors, and their inability to do so may be related to an increase in tyrosine hydroxylase and a decrease in DR in the olfactory bulb. In mice with an excised olfactory bulb, tyrosine hydroxylase decreases in the caudate and putamen nuclei, and DR increases in the nucleus accumbens, indicating a strong relationship between olfactory function and dopamine metabolism in the striatum.…”

Section: Some Features In Pet/spect Molecular Imaging As Reflected Bysupporting

confidence: 86%

Positron emission computed tomography/single photon emission computed tomography in Parkinson disease

Yao

Zheng

et al. 2020

Chinese Medical Journal

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Parkinson disease (PD) is the second-most common neurodegenerative disorder. Its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra and the damage of dopaminergic neurons caused by the abnormal deposition of a Lewy body, leading to a decreased dopamine level. Positron emission computed tomography (PET)/single photon emission computed tomography (SPECT) is a molecular imaging technology that can directly or indirectly reflect changes in molecular levels by using a specific tracer. With the research and development on the tracers of related enzymes for labeling dopamine transporter and dopamine receptor and for being involved in dopamine formation, this imaging technology has been applied to all aspects of PD research. It not only contributes to clinical work but also provides an important theoretical basis for exploring the pathological mechanism of PD at a molecular level. Therefore, this review discusses the application value of PET/SPECT in PD in terms of early diagnosis, disease severity evaluation, clinical manifestations, differential diagnosis, and pathological mechanism.

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Section: Some Features In Pet/spect Molecular Imaging As Reflected Bysupporting

confidence: 86%

Positron emission computed tomography/single photon emission computed tomography in Parkinson disease

Yao

Zheng

et al. 2020

Chinese Medical Journal

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“…Greater availability of DATs in the caudate nucleus and putamen, as measured with SPECT in healthy human individuals, has been associated with higher olfactory performance [92]. Interestingly, one study found evidence of decreased dopamine uptake in the caudate nucleus in Parkinson's disease (PD) patients with and without olfactory impairments [89]. Although PD patients constitute a particular clinical group, the results support the link between dopamine function and olfactory perception.…”

Section: Dopamine Modulation Of Sensory Inputsmentioning

confidence: 93%

Lost in Translation? On the Need for Convergence in Animal and Human Studies on the Role of Dopamine in Diet-Induced Obesity

et al. 2019

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Purpose of Review Animal and human studies suggest that diet-induced obesity and plasticity in the central dopaminergic system are linked. However, it is unclear whether observed changes depend on diet or obesity, and whether they are specific to brain regions and cognitive functions. Here, we focus on neural and cognitive changes in frontostriatal circuits. Recent Findings Both diet and obesity affect dopaminergic transmission. However, site and direction of effects are inconsistent across species and studies. Non-specific changes are observed spanning all frontostriatal loops, from sensory input to motivated behaviour. Given the impact of peripheral signals on central dopaminergic signalling and the interaction between the frontostriatal loops, modulation of dopamine likely propagates through all loops and, thus, affects behaviour on various levels of complexity. Summary To improve convergence between animal and human studies on diet-induced obesity, animal studies should include sophisticated cognitive measures and diets resembling human obesogenic diets, and human studies should adopt diet interventions and longitudinal designs.

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“…Hyposmic PD shows significantly reduced DAT ( 18 F-FP--CIT) binding in bilateral caudates and in left anterior and posterior putamen compared to normosmic PD patients [96]. Also the degree of DAT uptake ( 18 F-FP-CIT, 11 C-β-CFT) in the hippocampus, amygdala and striatum, VMAT2 ( 11 C-dihydrotetrabenazine) in the striatum and AChE activity tracer ( 11 C-MP4P) in the hippocampus, amygdala and neocortex correlates with the University of Pennsylvania Smell Identification Test (UPSIT) scores [87,102,103].…”

Section: Non-motor Dysfunctions In Pdmentioning

confidence: 99%

Positron emission tomography neuroimaging in neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis

Barć

Kuźma‐Kozakiewicz

2019

Neurol Neurochir Pol.

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Neurodegenerative diseases are a growing problem of ageing societies. Their insidious onset, and the lack of reliable biomarkers, result in significant diagnosis delays. This article summarises the results of studies on the use of positron emission tomography (PET) in the diagnosis of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. It focuses on clinical-pathogenetic aspects of individual diseases, as well as disease-specific patterns relevant in differential diagnosis and in assessing the risk of disease development and prognosis.

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Striatal dopamine uptake and olfactory dysfunction in patients with early Parkinson's disease

Cited by 39 publications

References 25 publications

Positron emission computed tomography/single photon emission computed tomography in Parkinson disease

Positron emission computed tomography/single photon emission computed tomography in Parkinson disease

Lost in Translation? On the Need for Convergence in Animal and Human Studies on the Role of Dopamine in Diet-Induced Obesity

Positron emission tomography neuroimaging in neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis

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