Stress-strain curve and young's modulus of a collagen molecule as determined by the X-ray diffraction technique

Sasaki, Naoki; Odajima, Singo

doi:10.1016/0021-9290(95)00110-7

Cited by 331 publications

(192 citation statements)

References 21 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…A very close agreement was found for hydrated collagen microfibril in the small strain regime between the FEM based results and experimental ones obtained by X-ray diffraction (Sasaki and Odajima, 1996) and also by atomic force microscopy (AFM) (Van der Rijt et al 2006;Aladin et al, 2010).…”

Section: Damping Capacitysupporting

confidence: 77%

See 1 more Smart Citation

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Barkaoui

Hambli

Tavares

2014

Computer Methods in Biomechanics and Biomedical Engineering

View full text Add to dashboard Buy / Rent full text

Bone is a multiscale heterogeneous material and its principal function is to support the body structure and to resist mechanical loads without fracturing. Numerical modelling of biocomposites at different length scales provides an improved understanding of the mechanical behaviour of structures such as bone, and also guides the development of multiscale mechanical models. Here, a three-dimensional nano-scale model of mineralized collagen microfibril based on the finite element method was employed to investigate the effect of material and structural factors on the mechanical equivalent of fracture properties.

show abstract

Section: Damping Capacitysupporting

confidence: 77%

“…Besides, the model does not take into account the mineral-collagen interface, which is also an issue to study in the near future. (Sasaki and Odajima, 1996), by atomic force microscopy (AFM) from (Van der Rijt et al…”

Section: Resultsmentioning

confidence: 99%

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Barkaoui

Hambli

Tavares

2014

Computer Methods in Biomechanics and Biomedical Engineering

View full text Add to dashboard Buy / Rent full text

show abstract

“…However, SAXS studies have demonstrated a linear forcedisplacement relation for collagen fibrils in the tendon [37,38] and MV tissue [39,40]. This is further corroborated by the atomistic modelling results by Buehler [41], where the forcedisplacement relation is essentially linear at strains lower than 0.35.…”

Section: Establishing and Modelling The Mechanical Behaviour Of The Nmentioning

confidence: 54%

A novel fibre-ensemble level constitutive model for exogenous cross-linked collagenous tissues

2016

View full text Add to dashboard Buy / Rent full text

Exogenous cross-linking of soft collagenous tissues is a common method for biomaterial development and medical therapies. To enable improved applications through computational methods, physically realistic constitutive models are required. Yet, despite decades of research, development and clinical use, no such model exists. In this study, we develop the first rigorous full structural model (i.e. explicitly incorporating various features of the collagen fibre architecture) for exogenously cross-linked soft tissues. This was made possible, in-part, with the use of native to cross-linked matched experimental datasets and an extension to the collagenous structural constitutive model so that the uncross-linked collagen fibre responses could be mapped to the cross-linked configuration. This allowed us to separate the effects of cross-linking from kinematic changes induced in the cross-linking process, which in turn allowed the non-fibrous tissue matrix component and the interaction effects to be identified. It was determined that the matrix could be modelled as an isotropic material using a modified Yeoh model. The most novel findings of this study were that: (i) the effective collagen fibre modulus was unaffected by cross-linking and (ii) fibre-ensemble interactions played a large role in stress development, often dominating the total tissue response (depending on the stress component and loading path considered). An important utility of the present model is its ability to separate the effects of exogenous cross-linking on the fibres from changes due to the matrix. Applications of this approach include the utilization in the design of novel chemical treatments to produce specific mechanical responses and the study of fatigue damage in bioprosthetic heart valve biomaterials.

show abstract

“…0.3 nm). In the presence of X-rays, the entire fibril acts as a molecular diffraction grating due to the periodicity of the collagen-mineral composite structure, which has led to numerous studies on the structure and mechanical properties of collagenous tissues using X-ray diffraction [13][14][15][16][17] . Figure 2a shows a representative small-angle X-ray diffraction pattern from an Arapaima scale in an unstressed state.…”

Section: Resultsmentioning

confidence: 99%

Mechanical adaptability of the Bouligand-type structure in natural dermal armour

et al. 2013

View full text Add to dashboard Buy / Rent full text

Arapaima gigas, a fresh water fish found in the Amazon Basin, resist predation by piranhas through the strength and toughness of their scales, which act as natural dermal armour. Arapaima scales consist of a hard, mineralized outer shell surrounding a more ductile core. This core region is composed of aligned mineralized collagen fibrils arranged in distinct lamellae. Here we show how the Bouligand-type (twisted plywood) arrangement of collagen fibril lamellae has a key role in developing their unique protective properties, by using in situ synchrotron small-angle X-ray scattering during mechanical tensile tests to observe deformation mechanisms in the fibrils. Specifically, the Bouligand-type structure allows the lamellae to reorient in response to the loading environment; remarkably, most lamellae reorient towards the tensile axis and deform in tension through stretching/sliding mechanisms, whereas other lamellae sympathetically rotate away from the tensile axis and compress, thereby enhancing the scale's ductility and toughness to prevent fracture.

show abstract

Stress-strain curve and young's modulus of a collagen molecule as determined by the X-ray diffraction technique

Cited by 331 publications

References 21 publications

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

Effect of material and structural factors on fracture behaviour of mineralised collagen microfibril using finite element simulation

A novel fibre-ensemble level constitutive model for exogenous cross-linked collagenous tissues

Mechanical adaptability of the Bouligand-type structure in natural dermal armour

Contact Info

Product

Resources

About