Stress Response to Surgery and Possible Ways of Its Correction

Ivanovs, Igors; Mihelsons, Māris; Boka, Viesturs

doi:10.2478/v10046-012-0014-z

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…Complications that accompany this anesthetic technique are rare and usually transient. 17 Ultrasound could be used as an adjuvant tool in caudal blocks because it can provide a real-time image and confirmation of the needle’s position in the epidural space. Also, intravascular and intrathecal injections can be avoided with ultrasound visualization and with previous aspiration.…”

Section: Discussionmentioning

confidence: 99%

Effects of caudal block in pediatric surgical patients: a randomized clinical trial

Benka

Pandurov

Galambos

et al. 2020

Brazilian Journal of Anesthesiology (English Edition)

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Section: Discussionmentioning

confidence: 99%

Effects of caudal block in pediatric surgical patients: a randomized clinical trial

Benka

Pandurov

Galambos

et al. 2020

Brazilian Journal of Anesthesiology (English Edition)

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“…Immune systems also activate the anti-inflammation response, which would modulate the proinflammatory phase, restoring homoeostasis. [7][8][9][10][11] In the majority of cases, the first 36 hours after trauma is dominated by activation of proinflammatory, followed with moderate immune suppression for the next few days. 3 12 Interleukin (IL)-6 is the essential proinflammatory cytokine associated with surgical trauma and the main cytokine responsible for inducing the acute phase response.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Single-centre, double-blind, randomised, parallel-group, superiority study to evaluate the effectiveness of general anaesthesia and ultrasound-guided transversus thoracis muscle plane block combination in adult cardiac surgery for reducing the surgical stress response: clinical trial protocol

et al. 2021

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IntroductionAdult open-heart surgery is a major surgery that causes surgical stress response and activation of the immune system, contributing further to postoperative complications. Transversus thoracis muscle plane block (TTPB) may potentially benefit in reducing the surgical stress response. This study aims to know the effectiveness of preoperative TTPB in adult open-heart surgery for reducing the surgical stress response.Methods and analysisThis study is a prospective, double-blind, randomised control trial comparing the combination of general anaesthesia and TTPB versus general anaesthesia only in adult open-heart surgery. Forty-two eligible subjects will be randomly assigned to the TTPB group or control group. The primary outcomes are the difference between the two groups in the means of postoperative cortisol and interleukin-6 plasma levels at 24 hours and 48 hours after cardiac intensive care unit admission. The secondary outcomes are the difference between the two groups in the means of total 24-hour postoperative morphine consumption and time of first postoperative patient-controlled analgesia (PCA) dose.Ethics and disseminationThe study protocol and informed consent forms have been reviewed and approved by the Ethics Committee of Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital. The result will be released to the medical community through presentation and publication in peer-reviewed journals.Trial registration numberNCT04544254.

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“…2 The modern medical practice aims to decrease surgically induced stress response, and many strategies have been introduced to overcome this issue. 3 The free radical formation increases secondary to ischemia-reperfusion, leukocyte activation, peritoneal injury, decreased perfusion in the visceral area, and mitochondrial dysfunction during laparotomy. 4 Because of the minimally invasive character, laparoscopic procedures may be attributed to the less production of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

2021

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Aims In this study, we aimed to investigate the anti‐inflammatory and antioxidant effects of intravenous ibuprofen by using the C‐reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker. Materials and Methods This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either pre‐emptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). The blood samples for thiol/disulfide homeostasis were collected as follows: before induction of anesthesia (T0), before pneumoperitoneum (T1), following postdeflation and discontinuation of anesthesia (T2), and postoperative 24th hour (T3). Simultaneous blood samples for C‐reactive protein (CRP) were also collected. The pre‐ and postoperative urea, creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels were measured. Results A total of 69 patients were included in the study. The patient's characteristics and intraoperative variables were comparable between groups (P > .05). The number of patients requiring rescue analgesia, the total amount of analgesic used, Visual Analog Scale (VAS) scores, and postoperative side effects were significantly lower in Group IP (P < .001). The decrease in native and total thiol levels at T1, T2, and T3 measurement points was significant in Group IP (P < .001). In both groups, the comparison to baseline values demonstrated no significant changes in terms of disulfide level (P > .05). The simultaneous CRP levels indicated a significant increase at the postoperative 24 hour in both groups (P < .001). The difference between groups was insignificant (P > .05). There was a significant increase in urea and creatinine levels in patients of Group IP (P < .05). Conclusion The pre‐emptive administration of ibuprofen provided effective pain control after gynecologic laparoscopy. However, ibuprofen changed the thiol/disulfide homeostasis in favor of oxidation and had no beneficial effect in surgically induced oxidative stress.

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Stress Response to Surgery and Possible Ways of Its Correction

Cited by 5 publications

References 57 publications

Effects of caudal block in pediatric surgical patients: a randomized clinical trial

Effects of caudal block in pediatric surgical patients: a randomized clinical trial

Single-centre, double-blind, randomised, parallel-group, superiority study to evaluate the effectiveness of general anaesthesia and ultrasound-guided transversus thoracis muscle plane block combination in adult cardiac surgery for reducing the surgical stress response: clinical trial protocol

The effects of pre‐emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C‐reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial

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