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This study was conducted to compare the serum level of Cortisol and Interleukin-6 (Stress Response) on eighteen clinically healthy mongrel male dogs of different ages (1-2 years old) with body weight ranged between 17-25 kg. Dogs were classified into two main groups open cholecystectomy and laparoscopic one. Anesthesia and postoperative management were identical in both groups. Serum level of cortisol was evaluated as a marker to assess surgical trauma and pain where it was measured before the operation (time 0) to obtain base line value and at 4 hours postoperatively. In addition, serum level of Interleukin-6 (IL-6) was evaluated also before the operation and at 4 and 24 hours after the surgery as a marker for the degree of systemic reaction to wide range of trauma. There was a significant (P < 0.05) lower concentration of serum cortisol in the laparoscopic group at four hours postoperatively than in the open surgery group. Serum levels of IL-6 during laparoscopic cholecystectomy were found to be significantly (P < 0.05) lower than that during open cholecystectomy at 4 and 24 hrs postoperatively. The current study concluded that the laparoscopic cholecystectomy with small skin incisions with the avoidance of open laparotomy and excessive manipulation of tissues can minimize surgical stress and provide more favorable postoperative conditions for dogs. This indicated that laparoscopic cholecystectomy is more recommendable than traditional open cholecystectomy.
This study was conducted to compare the serum level of Cortisol and Interleukin-6 (Stress Response) on eighteen clinically healthy mongrel male dogs of different ages (1-2 years old) with body weight ranged between 17-25 kg. Dogs were classified into two main groups open cholecystectomy and laparoscopic one. Anesthesia and postoperative management were identical in both groups. Serum level of cortisol was evaluated as a marker to assess surgical trauma and pain where it was measured before the operation (time 0) to obtain base line value and at 4 hours postoperatively. In addition, serum level of Interleukin-6 (IL-6) was evaluated also before the operation and at 4 and 24 hours after the surgery as a marker for the degree of systemic reaction to wide range of trauma. There was a significant (P < 0.05) lower concentration of serum cortisol in the laparoscopic group at four hours postoperatively than in the open surgery group. Serum levels of IL-6 during laparoscopic cholecystectomy were found to be significantly (P < 0.05) lower than that during open cholecystectomy at 4 and 24 hrs postoperatively. The current study concluded that the laparoscopic cholecystectomy with small skin incisions with the avoidance of open laparotomy and excessive manipulation of tissues can minimize surgical stress and provide more favorable postoperative conditions for dogs. This indicated that laparoscopic cholecystectomy is more recommendable than traditional open cholecystectomy.
Objective: The control of perioperative pain and its practice can play an important role in short and long term postoperative convalescence. The aim of this study was to evaluate the effect of dexmedetomidine on postoperative pain in patients undergoing abdominal hysterectomy (TAH). Methods: This double-blind, randomized controlled clinical trial study was conducted on 70 women aged 35-65 years undergoing general anaesthesia for TAH. In dexmedetomidine group, immediately after induction, a bolus dose of dexmedetomidine 1 μg/kg was injected for 15 minutes and then a dose of infusion 0.5 μg/kg until the end of surgery. In the control group, normal saline was injected. Patients were evaluated for pain intensity according to the visual analogue scale (VAS), the amount of analgesic use during 24 hours after surgery and time of administration of the first dose of pethidine. Results: Although the mean pain intensity at all times in dexmedetomidine group was lower than the control group, there was a significant difference at 4, 8, 16, and 24 hours after surgery (P <0.05). The time of the first request for administration of the first dose of pethidine was greater than the control group, but there was no significant difference in first-time administration of opioid in the two groups (P >0.05). Although the mean dose of pethidine was lower in the dexmedetomidine group, there was no statistically significant difference between the mean values in the two groups (P >0.05). Conclusion: This study showed the efficacy of dexmedetomidine in reducing post-operative pain and receiving pethidine after surgery.
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