Stress promotes major changes in dopamine receptor densities within the mesoaccumbens and nigrostriatal systems

Cabib, Simona; Giardino, Luciana; Calzà, Laura; Zanni, Massimo; Mele, Andrea; Puglisi-Allegra, Stefano

doi:10.1016/s0306-4522(97)00468-5

Cited by 93 publications

(66 citation statements)

References 53 publications

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“…In agreement, a number of studies have shown that there is a reduced level of DA and its metabolites in the CSF of depressed patients (Brown and Gershon, 1993) and also a reduced release and metabolism of DA in the basal ganglia of animals subjected to stressors that induce behavioral depression (Cabib and Puglisi-Allegra, 1996). This reduction, however, does not appear to be caused by a direct impairment of the dopaminergic neurons or postsynaptic receptors themselves (Weiss et al, 1996;Cabib et al, 1998;Ossowska et al, 2001;Herman et al, 1984;ZebrowskaLupina et al, 1988), but may occur instead in an afferent system that modulates dopaminergic function. One such afferent system that is particularly sensitive to stress and has been implicated in depressive illness is the a 1 -adrenergic (Lipinski et al, 1987;.…”

Section: Role Of a 1 -Adrenoceptors In Behavioral Activitymentioning

confidence: 66%

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Stone

Yang

Rosengarten

et al. 2003

Neuropsychopharmacol

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Currently, most basic and clinical research on depression is focused on either central serotonergic, noradrenergic, or dopaminergic neurotransmission as affected by various etiological and predisposing factors. Recent evidence suggests that there is another system that consists of a subset of brain a 1B -adrenoceptors innervated primarily by brain epinephrine (EPI) that potentially modulates the above three monoamine systems in parallel and plays a critical role in depression. The present review covers the evidence for this system and includes findings that brain a 1 -adrenoceptors are instrumental in behavioral activation, are located near the major monoamine cell groups or target areas, receive EPI as their neurotransmitter, are impaired or inhibited in depressed patients or after stress in animal models, and are restored by a number of antidepressants. This 'EPI-a 1 system' may therefore represent a new target system for this disorder.

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Section: Role Of a 1 -Adrenoceptors In Behavioral Activitymentioning

confidence: 66%

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Stone

Yang

Rosengarten

et al. 2003

Neuropsychopharmacol

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“…* different from both Vag ϩ Stress and Anox ϩ Stress at p Ͻ .01; ss ϭ different from C sec (no stress) at p Ͻ .001; s ϭ different from C sec (no stress) at p Ͻ .01. stress in rats born by C-section compared to vaginal birth. Previous work with inbred mouse strains suggested that genetic composition influences adaptation of DA receptors to stress (Puglisi-Allegra and Cabib 1997;Cabib et al 1998). The present study indicates that an early environmental insult, namely C-section birth, can also lastingly influence adaptive responses of DA receptors to stress.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, stress can alter brain DA receptor responsivity (see review by Puglisi-Allegra and Cabib 1997). However few studies have assessed stress-induced changes in DA receptor densities in animal models (Papp et al 1994;Pothos et al 1995;Cabib et al 1998;Giardino et al 1998) and none have investigated whether stress-induced modulation of DA receptors is altered by birth insult.…”

mentioning

confidence: 99%

Caesarean Section Birth Produces Long Term Changes in Dopamine D1 Receptors and in Stress-induced Regulation of D3 and D4 Receptors in the Rat Brain

El-Khodor

Boksa

2001

Neuropsychopharmacology

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“…Stress, however, reduces VTA DA receptors in DBA/2 mice and increases them in C57BL/6 mice (Cabib et al 1998). Moreover, stressed DBA/2 mice show enhanced locomotor response to amphetamine challenge (Badiani et al 1992;Cabib et al 1995;Cabib & Bonaventura 1997), reduced sensitivity to behavioral inhibition promoted by acute stress experiences (Cabib & Puglisi-Allegra 1996;Cabib et al 1995;, and spontaneous stereotyping (Cabib & Bonaventura 1997).…”

Section: Introductionmentioning

confidence: 99%

“…A classic genetic analysis as well as an analysis of quantitative trait loci in recombinant inbred strains indicated that mesoaccumbens DA autoreceptor density is a polygenic trait controlled by a major genotype stress interaction that involves genes controlling regulatory factors related to stress response (such as CRH-and steroid-related products) and neural or synaptic plasticity (such as rate-limiting factors for protein synthesis, potassium channel proteins, glutamate, and gangliosides) . These observations support a major role for variability in VTA D2 DA receptors in phenotypic variability related to the functional capacity of VTA DA projections.Stress, however, reduces VTA DA receptors in DBA/2 mice and increases them in C57BL/6 mice (Cabib et al 1998). Moreover, stressed DBA/2 mice show enhanced locomotor response to amphetamine challenge (Badiani et al 1992;Cabib et al 1995;Cabib & Bonaventura 1997), reduced sensitivity to behavioral inhibition promoted by acute stress experiences (Cabib & Puglisi-Allegra 1996;Cabib et al 1995;, and spontaneous stereotyping (Cabib & Bonaventura 1997).…”

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confidence: 99%

Steps to a neurochemistry of personality

Lawrence¹,

Koepp²,

Gunn³

et al. 1999

Behav Brain Sci

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Extraversion has two central characteristics: (1) interpersonal engagement, which consists of affiliation (enjoying and valuing close interpersonal bonds, being warm and affectionate) and agency (being socially dominant, enjoying leadership roles, being assertive, being exhibitionistic, and having a sense of potency in accomplishing goals) and (2) impulsivity, which emerges from the interaction of extraversion and a second, independent trait (constraint). Agency is a more general motivational disposition that includes dominance, ambition, mastery, efficacy, and achievement. Positive affect (a combination of positive feelings and motivation) is closely associated with extraversion. Extraversion is accordingly based on positive incentive motivation.Parallels between extraversion (particularly its agency component) and a mammalian behavioral approach system based on positive incentive motivation implicate a neuroanatomical network and modulatory neurotransmitters in the processing of incentive motivation. A corticolimbic-striatal-thalamic network (1) integrates the salient incentive context in the medial orbital cortex, amygdala, and hippocampus; (2) encodes the intensity of incentive stimuli in a motive circuit composed of the nucleus accumbens, ventral pallidum, and ventral tegmental area dopamine projection system; and (3) creates an incentive motivational state that can be transmitted to the motor system.Individual differences in the functioning of this network arise from functional variation in the ventral tegmental area dopamine projections, which are directly involved in coding the intensity of incentive motivation. The animal evidence suggests that there are three neurodevelopmental sources of individual differences in dopamine: genetic, "experience-expectant," and "experience-dependent." Individual differences in dopamine promote variation in the heterosynaptic plasticity that enhances the connection between incentive context and incentive motivation and behavior.Our psychobiological threshold model explains the effects of individual differences in dopamine transmission on behavior, and their relation to personality traits is discussed.Keywords: behavioral sensitization; dopamine; extraversion; heterosynaptic plasticity; incentive motivation; neurobiology; personality the behavioral, emotional, and motivational characteristics of extraversion. Next, we identified a mammalian behavior pattern with corresponding characteristics, as described in the psychological and ethological literatures. Once an analogous motivation was identified, animal neurobiological research provided empirical links to its neural organization and neurochemical modulation. These hypotheses were then extended to humans and subjected to empirical tests. Extraversion: Central characteristics and underlying motivationExtraversion is a higher-order trait that is derived from a set of correlated lower-order traits. The lower-order traits are measures of behavioral and emotional characteristicssuch as social dominance, positive emo...

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Stress promotes major changes in dopamine receptor densities within the mesoaccumbens and nigrostriatal systems

Cited by 93 publications

References 53 publications

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Caesarean Section Birth Produces Long Term Changes in Dopamine D1 Receptors and in Stress-induced Regulation of D3 and D4 Receptors in the Rat Brain

Steps to a neurochemistry of personality

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