Stress-induced mobility of OPHIO1 and OPHIO2, DNA transposons of the Dutch elm disease fungi

Bouvet, Guillaume F.; Jacobi, Volker; Plourde, Karine V.; Bernier, Louis

doi:10.1016/j.fgb.2007.12.007

Cited by 39 publications

(27 citation statements)

References 59 publications

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“…A relatively small portion of the genome is occupied by repeat sequences, however the mechanism of repeat-induced point mutation (RIP; see below) appears active in this genome. A genome-to-genome alignment between O. novo-ulmi H327 against the appropriate scaffold from O. ulmi W9 showed a large region around the previously mentioned MAT1 locus has very high identity between the two, consistent with the hypothesis of Paoletti et al (2006) (Bouvet et al 2007(Bouvet et al , 2008. OPH-IO transposons occur in low copy number (less than 10 copies) per genome, suggesting that they appeared recently in ophiostomatoid genomes.…”

Section: Obtained Epg1supporting

confidence: 70%

“…This hypothesis is supported by the observation that OPHIO1 and OPH-IO2 are restricted to O. ulmi and O. novo-ulmi subsp. novo-ulmi (Bouvet et al 2007) and can be induced to move from their genomic location by various biotic and abiotic stresses (Bouvet et al 2008), which are two characteristics of a recent invasion. Based on the high variability of its Southern hybridization profiles, OPHIO2 seems to have the highest level of mobility among OPHIO TEs.…”

Section: Obtained Epg1mentioning

confidence: 99%

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Genomics of the Dutch elm disease pathosystem: are we there yet?

Bernier¹,

Aoun²,

Bouvet³

et al. 2015

iForest

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Section: Obtained Epg1supporting

confidence: 70%

Section: Obtained Epg1mentioning

confidence: 99%

Genomics of the Dutch elm disease pathosystem: are we there yet?

Bernier¹,

Aoun²,

Bouvet³

et al. 2015

iForest

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“…We have shown that transposition can be activated by exposing cultures to low temperatures and deactivated again by raising the temperature. Modulation of transposition activity by environmental factors was described recently for the transposable elements Aft1 of A. fumigatus, crawler of A. oryzae, and OPHIO1 of Ophiostoma ulmi (1,16,39). crawler, which shows high levels of sequence identity to impala, is activated in the presence of low millimolar levels of copper sulfate, while both crawler and Aft1 have increased levels of transposition in response to heat shock.…”

Section: Discussionmentioning

confidence: 84%

The Transposon impala Is Activated by Low Temperatures: Use of a Controlled Transposition System To Identify Genes Critical for Viability of Aspergillus fumigatus

Carr¹,

Tuckwell²,

Hey³

et al. 2010

Eukaryot Cell

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Genes that are essential for viability represent potential targets for the development of anti-infective agents. However, relatively few have been determined in the filamentous fungal pathogen Aspergillus fumigatus. A novel solution employing parasexual genetics coupled with transposon mutagenesis using the Fusarium oxysporum transposon impala had previously enabled the identification of 20 essential genes from A. fumigatus; however, further use of this system required a better understanding of the mode of action of the transposon itself. Examination of a range of conditions indicated that impala is activated by prolonged exposure to low temperatures. This newly identified property was then harnessed to identify 96 loci that are critical for viability in A. fumigatus, including genes required for RNA metabolism, organelle organization, protein transport, ribosome biogenesis, and transcription, as well as a number of noncoding RNAs. A number of these genes represent potential targets for much-needed novel antifungal drugs.

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“…(68) Indeed, many plant TEs were discovered because of their stress-induced phenotypes. (69) Subsequent research has revealed stressinduced activation and/or increased TE expression in fungi, (70) corals, (71) insects, (72) crustaceans, (73) and mammals. (74) In D. melanogaster, transposition rate of the TE Dm-412 increased by two orders of magnitude after heat shock treatment.…”

Section: Transposable Elements Drive the Evolution Of Epigenetic Silementioning

confidence: 99%

Transposable elements and an epigenetic basis for punctuated equilibria

2009

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Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by longterm stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug-of-war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their capacity to drive non-adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This ''epi-transposon hypothesis'' can not only explain macroevolutionary tempo and mode, but may also resolve other long-standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge.

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Stress-induced mobility of OPHIO1 and OPHIO2, DNA transposons of the Dutch elm disease fungi

Cited by 39 publications

References 59 publications

Genomics of the Dutch elm disease pathosystem: are we there yet?

Genomics of the Dutch elm disease pathosystem: are we there yet?

The Transposon impala Is Activated by Low Temperatures: Use of a Controlled Transposition System To Identify Genes Critical for Viability of Aspergillus fumigatus

Transposable elements and an epigenetic basis for punctuated equilibria

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