Stress-induced hyperalgesia instead of analgesia in patients with chronic musculoskeletal pain

Löffler, Martin; Schneider, Pia; Schuh‐Hofer, Sigrid; Kamping, Sandra; Usai, Katrin; Treede, Rolf‐Detlef; Nees, Frauke; Flor, Herta

doi:10.1016/j.ynpai.2022.100110

Cited by 9 publications

(6 citation statements)

References 85 publications

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“…10,23 Furthermore, HPA-axis and SAM responses increase following situations, such as physical exercise and excitement, which are not necessarily threatening. 57,60 Such findings have resulted in defining stress as a “cognitive perception of uncontrollability and unpredictability,” 50 thus emphasizing the importance of assessing individual appraisal in addition to the physiological changes, as done in this study.…”

Section: Discussionmentioning

confidence: 88%

“…That said, many of the experimental studies assessing pain responses following acute stress manipulation have either included only men 38,43 or male animals 3,54,55 or included both sexes but did not compare between them. 16,23,29,60,63 Only a few studies have directly examined sex effects in pain-stress interactions. In 2 studies, only women exhibited increase in pain threshold or pain tolerance following stress manipulation, namely, stress-induced analgesia (SIA).…”

Section: Introductionmentioning

confidence: 99%

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Sex effects in the interaction of acute stress and pain perception

Geva

Golan

Pinchas

et al. 2022

Pain

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Sex effects in the interaction of acute stress and pain perception

Geva

Golan

Pinchas

et al. 2022

Pain

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“…Under normal conditions, SIA may inhibit the occurrence of SIH, thereby reducing the sensation of pain. However, the phenomenon of SIA may be overshadowed by the more commonly observed SIH (Loffler et al., 2023), or SIA may switch to SIH in some cases (Donello et al., 2011). In general, SIA and SIH are two different effects of stress on pain response, and the relationship between them is complex.…”

Section: Limitationsmentioning

confidence: 99%

Sex differences in stress‐induced hyperalgesia and its mechanisms

Gao,

Liu,

et al. 2023

J of Neuroscience Research

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Chronic stress induces a variety of physiological and/or psychological abnormalities, including hyperalgesia. Researchers have discovered sex differences in the prevalence of stress‐induced hyperalgesia (SIH) in recent years. Sex differences may be one of the reasons for the heterogeneity of susceptibility to stress‐related diseases. In this review, the potential mechanisms of sex differences in SIH are discussed, such as hypothalamus–pituitary–adrenal axis responses, regulation of sex hormones, and immune system responses.

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“…The concept of increased nerve sensitivity (hyperalgesia and allodynia) is a clinical presentation that does not imply a mechanism but has been identified during studies where individuals have reduced pain pressure thresholds when encountering a stress enhanced environment or situation [ 64 , 65 ]. The analgesic effect of stress depends on the type of stressor, but it can also differ between patients, particularly those with chronic pain [ 66 ]. Besides pain modulation, stress can induce or worsen other complaints, such as fatigue or cognitive symptoms, in people with chronic pain [ 67 , 68 , 69 ].…”

Section: State Of the Artmentioning

confidence: 99%

The Biology of Chronic Pain and Its Implications for Pain Neuroscience Education: State of the Art

Zimney

Bogaert

Louw

2023

JCM

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Pain is an individualized experience for the person suffering from chronic pain. Significant strides have been made in the last few decades in understanding various biological changes that coincide with chronic pain. This state-of-the-art overview looks at the current evidence related to the biology of chronic pain and the implications these findings have on the delivery of pain neuroscience education (PNE). The paper summarizes the various (epi)genetic, neural, endocrine, and immune factors discovered and explored in the scientific literature concerning chronic pain. Each of these biological factors has various implications for the content and delivery of PNE. We discuss the future directions these biological factors have for the clinical implementation of PNE by linking the importance of behavior change, optimizing the learning environment, and using an individualized multimodal treatment approach with PNE. In addition, future directions for research of PNE based on these biological factors are provided with importance placed on individualized patient-centered care and how PNE can be used with traditional modes of care and growing trends with other care methods. PNE was originally and continues to be rooted in understanding chronic pain biology and how that understanding can improve patient care and outcomes.

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Stress-induced hyperalgesia instead of analgesia in patients with chronic musculoskeletal pain

Cited by 9 publications

References 85 publications

Sex effects in the interaction of acute stress and pain perception

Sex effects in the interaction of acute stress and pain perception

Sex differences in stress‐induced hyperalgesia and its mechanisms

The Biology of Chronic Pain and Its Implications for Pain Neuroscience Education: State of the Art

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