Stress-induced endogenous-dsRNAs drive beta-cells to IFN-I state
Kevin K. Chi,
Parijat Senapati,
Amy Leung
et al.
Abstract:Aims/hypothesisEndogenous dsRNAs originating from retrotransposons within the human genome have the potential to trigger autoimmunogenic recognition via RIG-like receptors such as MDA5. This phenomenon, known as “viral mimicry”, induces potent interferon-beta expression, resulting in cell death and potential collateral death to surrounding cells. Viral mimicry has been mostly studied in relation to epigenetic therapeutics, although there are indications the phenomenon is relevant in other physiological context… Show more
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