Stress-induced alterations in catecholamine enzymes gene expression in the hypothalamic dorsomedial nucleus are modulated by caudal brain and not hypothalamic paraventricular nucleus neurons

Mravec, Boris; Lukackova, Renata; Bodnár, Ibolya; Kiss, Alexander; Pacák, Karel; Palkovits, Miklós; Květňanský, Richard

doi:10.1016/j.brainresbull.2007.06.005

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…Several of these stressors also increased the activity and protein level of TH and DBH in the noradrenergic neurons (Serova et al ., ; Sabban & Kvetnansky, ; Wong & Tank, ). Moreover, the stress‐triggered increase in the activity of catecholamine biosynthetic enzymes is accompanied by changes in their respective mRNAs (Watanabe et al ., ; Rusnak et al ., ; Wang et al ., ; Mravec et al ., ). The results obtained previously by our group revealed that the TH and DBH transcription initiation rate increased with a single IMO (Serova et al ., ; Kvetnansky et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Effect of a single and repeated stress exposure on gene expression of catecholamine biosynthetic enzymes in brainstem catecholaminergic cell groups in rats

Mravec

Vargovič

Filipčík

et al. 2015

Eur J of Neuroscience

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Brainstem catecholaminergic neurons significantly participate in the regulation of neuroendocrine system activity, particularly during stressful conditions. However, so far the precise quantitative characterisation of basal and stress-induced changes in gene expression and protein levels of catecholaminergic biosynthetic enzymes in these neurons has been missing. Using a quantitative reverse transcription-polymerase chain reaction method, we investigated gene expression of catecholamine biosynthetic enzymes in brainstem noradrenergic and adrenergic cell groups in rats under resting conditions as well as in acutely and repeatedly stressed animals. For the first time, we described quantitative differences in basal levels of catecholamine biosynthetic enzyme mRNA in brainstem catecholaminergic ascending and descending projecting cell groups. Moreover, we found and defined some differences among catecholaminergic cell groups in the time-course of mRNA levels of catecholaminergic enzymes following a single and especially repeated immobilisation stress. The data obtained support the assumption that brainstem catecholaminergic cell groups represent a functionally differentiated system, which is highly (but specifically) activated in rats exposed to stress. Therefore, potential interventions for the treatment of stress-related diseases need to affect the activity of brainstem catecholaminergic neurons not uniformly but with some degree of selectivity.

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Section: Discussionmentioning

confidence: 97%

Effect of a single and repeated stress exposure on gene expression of catecholamine biosynthetic enzymes in brainstem catecholaminergic cell groups in rats

Mravec

Vargovič

Filipčík

et al. 2015

Eur J of Neuroscience

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“…The effective biological processes of the LRP11 gene include response to heat, cold, hunger, mechanical stimuli and stress. In general, the LRP11 gene is an integral part of the cell membrane (22)(23). The molecular functions of the FUBP1 gene include binding to nucleic acid, DNA, RNA, and pro- Figures 4, 5, and 6 show the different QMEAN z-scores, including QMEAN, Cβ interactions, all-atom interactions, solvation, and torsion for the LRP11, FUBP1, and TET1 genes.…”

Section: Ontology Of Lrp11 Fubp1 and Tet1 Genesmentioning

confidence: 99%

The expression and clinical value of LRP11, FUBP1 and TET1 in cervical cancer

Xiaojie Zhao,

Suhua Li,

Jiexin Wen

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Hypertensive response to stress: The role of histaminergic H1 and H2 receptors in the medial amygdala

Almeida

Ferreira

Pereira

et al. 2015

Physiology & Behavior

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Different brain areas seem to be involved in the cardiovascular responses to stress. The medial amygdala (MeA) has been shown to participate in cardiovascular control, and acute stress activates the MeA to a greater extent than any of the other amygdaloid structures. It has been demonstrated that the brain histaminergic system may be involved in behavioral, autonomic and neuroendocrine responses to stressful situations. The aim of the present study was to investigate the role of the histaminergic receptors H1 and H2 in cardiovascular responses to acute restraint stress. Wistar rats (280-320g) received bilateral injections of cimetidine, mepyramine or saline into the MeA and were submitted to 45min of restraint stress. Mepyramine microinjections at doses of 200, 100 and 50nmol promoted a dose-dependent blockade of the hypertensive response induced by the restraint stress. Cimetidine (200 and 100nmol) promoted a partial blockade of the hypertensive response to stress only at the highest dose administered. Neither drugs altered the typical stress-evoked tachycardiac responses. Furthermore, mepyramine and cimetidine were unable to modify the mean arterial pressure or heart rate of freely moving rats under basal conditions (non-stressed rats). The data suggest that in the MeA the histaminergic H1 receptors appear to be more important than H2 receptors in the hypertensive response to stress. Furthermore, there appears to be no histaminergic tonus in the MeA controlling blood pressure during non-stress conditions.

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Stress-induced alterations in catecholamine enzymes gene expression in the hypothalamic dorsomedial nucleus are modulated by caudal brain and not hypothalamic paraventricular nucleus neurons

Cited by 4 publications

References 52 publications

Effect of a single and repeated stress exposure on gene expression of catecholamine biosynthetic enzymes in brainstem catecholaminergic cell groups in rats

Effect of a single and repeated stress exposure on gene expression of catecholamine biosynthetic enzymes in brainstem catecholaminergic cell groups in rats

The expression and clinical value of LRP11, FUBP1 and TET1 in cervical cancer

Hypertensive response to stress: The role of histaminergic H1 and H2 receptors in the medial amygdala

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