Stress granules dynamics: benefits in cancer

Abstract

Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and pathological condition. During tumorigenesis, cancer cells are repeatedly exposed to diverse stress stimuli from the tumor microenvironment, and the dynamics of SGs is often modulated due to the alteration of gene expression patterns in cancer cells, leading to tumor progression as well as resistance to anticancer treatment. In this mini review, we provide a brief discussion about our current understanding of the fundamental roles of SGs during physiological stress and the effect of dysregulated SGs on cancer cell fitness and cancer therapy. [

Escherichia coli‐Induced cGLIS3‐Mediated Stress Granules Activate the NF‐κB Pathway to Promote Intrahepatic Cholangiocarcinoma Progression

“…[ 37,38 ] Previous studies have reported that SGs influence the malignant behavior of tumors, particularly their invasion, migration, and drug resistance. [ 12,16 ] Our research showed that ICC stimulated with E. coli exhibited enhanced migratory ability and chemoresistance. A significant increase in the number of SGs was observed.…”

“…[10] Stress granules (SGs) play a crucial role in cell survival during bacterial infection by responding to microenvironmental stimuli. [11][12][13] These granules protect cells from stress-induced damage and death by sequestering numerous ribonucleoprotein particles (RNPs) and signaling proteins. [14,15] This mechanism is essential for promoting cell survival under physiological and pathological conditions.…”

“…[16] However, it has been reported that cancer cells exploit SGs to facilitate distant metastasis and tumor chemoresistance. [12] Circular RNAs (circRNAs) can regulate cellular stress. Some circRNAs play crucial roles in maintaining homeostasis, whereas others when dysregulated, may enhance the stress response to adapt to chronic stress during cancer development.…”

“…[ 16 ] However, it has been reported that cancer cells exploit SGs to facilitate distant metastasis and tumor chemoresistance. [ 12 ]…”

Identification and validation of a novel defined stress granule-related gene signature for predicting the prognosis of ovarian cancer via bioinformatics analysis

“…SGs are dynamically regulated (Protter & Parker, 2016). It occurs under stress conditions or cancer drug treatment and usually disappears after recovery from stress (Lee & Namkoong, 2022). Tumors are often faced with stressful environments.…”