Stress Cardiomyopathy Diagnosis and Treatment

Chazal, Horacio Medina de; Buono, Marco Giuseppe Del; Keyser-Marcus, Lori; Ma, Liangsuo; Moeller, F. Gerard; Berrocal, Daniel; Abbate, Antonio

doi:10.1016/j.jacc.2018.07.072

Cited by 412 publications

(519 citation statements)

References 125 publications

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“…6 In contrast, stress cardiomyopathy, also known as takotsubo syndrome, is predominantly characterized by isolated left ventricular dysfunction and only in a minority of patients by right ventricular involvement. 7 However, it may be difficult to diagnose and differentiate between acute right-sided and left-sided heart failure based on clinical presentation. Moreover, ECG changes depicting right ventricular strain are not sensitive to diagnose acute right-sided heart failure.…”

Section: Discussionmentioning

confidence: 99%

Fatal right‐sided heart failure due to leukostasis in a patient with leukemic transformation of myelodysplastic syndrome

Pryds

Rasmussen

Andersen

2018

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Fatal right‐sided heart failure due to leukostasis in a patient with leukemic transformation of myelodysplastic syndrome

Pryds

Rasmussen

Andersen

2018

Clinical Case Reports

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“…The role of stress (Takotsubo) cardiomyopathy in COVID-19 related cardiac injury is not known at this time, with no cases in the literature currently. However, several of the proposed mechanisms of COVID-19 related cardiac injury detailed in this review are also thought to be implicated in the pathophysiology of stress cardiomyopathy, particularly those of microvascular dysfunction, cytokine storm and sympathetic surge (95).…”

Section: Stress Cardiomyopathymentioning

confidence: 99%

COVID-19 for the Cardiologist

Atri

Siddiqi

Lang

et al. 2020

JACC: Basic to Translational Science

265

137

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Highlights-Severe acute respiratory virus-2 (SARS-CoV2), the infection responsible for coronavirus disease-2019 (COVID-19), has spread globally leading to a devastating loss of life. In a few short months, the clinical and scientific communities have rallied to rapidly evolve our understanding of the mechanism(s) of disease and potential therapeutics. -This review discusses the current understanding of the basis virology of SARS-CoV2 and the epidemiology, clinical manifestations, including cardiovascular, and mortality of COVID-19. A detailed review of the viral life cycle and putative mechanism(s) of injury frames the discussion of possible preventative and therapeutic strategies. -The ongoing, unprecedented collective effort will, without a doubt, advance our ability to prevent the spread and optimally care for patients suffering from COVID-19. SummaryThe coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease.We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.

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“…9 Echocardiography shows a classic pattern of wall-motion abnormality with hypokinesis of the mid-and apical left ventricle (LV) with sparing of the basal segments-the basal myocardium usually shows compensatory hyperkinesis. 15 All 3 conditions present with acute chest pain, elevated troponin, ischemic findings on EKG, 16 There have been temporal patterns described with time of week, day, and even season of the year being more likely to be associated with TC, for example most series have described a summer preference for TC. TC with an emotional or no trigger is termed primary, whereas that occurring in sepsis, trauma, intracranial bleeds, or similar acute illnesses is termed secondary.…”

Section: Introductionmentioning

confidence: 99%

“…14 In the acute stages, the diagnosis can be challenging to make because of similarities with acute coronary syndrome (ACS) or myocarditis. 15 All 3 conditions present with acute chest pain, elevated troponin, ischemic findings on EKG, 16 and wall-motion abnormalities on echocardiography. 17 Often, invasive coronary angiography is the first diagnostic test in a patient with acute chest pain and elevated cardiac biomarkers, especially if there is ST elevation or ongoing chest pain.…”

Section: Introductionmentioning

confidence: 99%

Takotsubo cardiomyopathy in a man with no trigger and multiple cardioembolic complications—A rare constellation

et al. 2019

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C ARDIAC MRI S e c tio n Edito r -Ro b e r t W.W. B ie d e rma n , M D a n d S e c tio n A sso ciate Edito r -G a rima A ro r a , M D Additional supporting information may be found online in the Supporting Information section at the end of the article.Movie S1. Initial echo (apical 4-chamber view) with LVEF 35%, hypokinesis of mid-and apical LV, preserved basal contractility and a large, mobile apical LV clot.Movie S2. Echo 1 wk later (apical 4-chamber view) with LVEF 65%-70%, and no thrombus.Movie S3. Cardiac MRI (4-chamber view) with LVEF 65%-70%, no thrombus, normal RV function, and a small pericardial effusion.How to cite this article: Kalra DK, Lichtenstein SJ, Bai C, et al.Takotsubo cardiomyopathy in a man with no trigger and multiple cardioembolic complications-A rare constellation.

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Stress Cardiomyopathy Diagnosis and Treatment

Cited by 412 publications

References 125 publications

Fatal right‐sided heart failure due to leukostasis in a patient with leukemic transformation of myelodysplastic syndrome

Fatal right‐sided heart failure due to leukostasis in a patient with leukemic transformation of myelodysplastic syndrome

COVID-19 for the Cardiologist

Takotsubo cardiomyopathy in a man with no trigger and multiple cardioembolic complications—A rare constellation

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