“…Stress causes several autonomic responses, including changes in heart rate, blood pressure, and respiration rate. Stress also raises body temperature (Bouwknecht et al (2007) E-mail address: swat@flet.keio.ac.jp b r a i n r e s e a r c h 1 6 2 4 ( 2 0 1 5 ) 1 3 4 -1 3 9 including a novel cage (Houtepen et al, 2011), social threat (Pardon et al, 2004), social defeat (Keeney et al, 2001), and restraint (Thornhill et al, 1979;van der Heyden et al, 1997;Van Eijl et al, 2006). SIH indicates a rise in the set point of thermoregulation (Oka et al, 2001) and has been used to examine the effect of anxiogenic drugs in rodents (see Vinkers et al (2008) for review).…”