Streptococcus pneumoniae invasive disease in the neonatal period: An increasing problem?

Simpson, John; Patel, Jayesh; Ispahani, P.

doi:10.1007/bf02074835

Cited by 25 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…S. pneumoniae is a relatively rare pathogen in neonatal sepsis (1-11%) [30], and a rare cause of neonatal skin colonization, yet when it occurs, the course of the disease has been reported to be more severe, particularly in EOS [31]. Early onset S. pneumoniae infection is often associated with maternal vaginal colonization or disease [32][33][34]. The bacterium can be difficult to culture, particularly following administration of intrapartum antibiotics [12,35], which could lead to under diagnosis based on blood culture data.…”

Section: Discussionmentioning

confidence: 99%

PCR for the detection of pathogens in neonatal early onset sepsis

et al. 2020

View full text Add to dashboard Cite

Background A large proportion of neonates are treated for presumed bacterial sepsis with broad spectrum antibiotics even though their blood cultures subsequently show no growth. This study aimed to investigate PCR-based methods to identify pathogens not detected by conventional culture. Methods Whole blood samples of 208 neonates with suspected early onset sepsis were tested using a panel of multiplexed bacterial PCRs targeting Streptococcus pneumoniae, Streptococcus agalactiae (GBS), Staphylococcus aureus, Streptococcus pyogenes (GAS), Enterobacteriaceae, Enterococcus faecalis, Enterococcus faecium, Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium, a 16S rRNA gene broadrange PCR and a multiplexed PCR for Candida spp. Results Two-hundred and eight samples were processed. In five of those samples, organisms were detected by conventional culture; all of those were also identified by PCR. PCR detected bacteria in 91 (45%) of the 203 samples that did not show bacterial growth in culture. S. aureus, Enterobacteriaceae and S. pneumoniae were the most frequently detected pathogens. A higher bacterial load detected by PCR was correlated positively with the number of clinical signs at presentation. Conclusion Real-time PCR has the potential to be a valuable additional tool for the diagnosis of neonatal sepsis.

show abstract

Section: Discussionmentioning

confidence: 99%

PCR for the detection of pathogens in neonatal early onset sepsis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Clinical manifestations of S pneumoniae infections in neonates and young infants are serious and include meningitis, sepsis, bacteremia, pneumonia, otitis media, abscesses, and bone and joint infections. [5][6][7][8][9][10][11] Whether PCV7 vaccination of children aged 2 months or older would protect neonates and young infants by changing pneumococcal carriage in those too young to receive PCV7, similar to that reported after Haemophilus influenza type b vaccination, 12 is unknown. We sought to determine the rates of IPDs among neonates and young infants in 8 states performing active, population-based laboratory surveillance.…”

mentioning

confidence: 99%

Invasive Pneumococcal Disease Among Infants Before and After Introduction of Pneumococcal Conjugate Vaccine

Poehling¹,

Talbot²,

Griffin³

et al. 2006

JAMA

421

235

View full text Add to dashboard Cite

show abstract

“…Geç neonatal S.pneumoniae enfeksiyonu ile başvuranlarda sepsis, bakteriyemi, menenjit ve pnömoni gibi invazif hastalıklar görülebildiği gibi, perforasyonlu bilateral otitis media da sıktır 1 . Yenidoğan döneminde invazif pnömokokal hastalıklarda mortalite oranı %14-60 arasında değişmektedir ve bu çalışmalarda mortalitenin yıllar içinde azaldığı dikkati çekmektedir 1,6,9 . Yine nörolojik sekel gibi ciddi morbiditelerin de %13 oranında görüldüğü bildirilmiştir 10 .…”

Section: Discussionunclassified

An Early Neonatal Sepsis Case Due to Streptococcus pneumoniae Serotype 7F

Alan¹,

Yildiz²,

Erdeve³

et al. 2013

Mikrobiyol Bul

View full text Add to dashboard Cite

Streptococcus pneumoniae infections which are relatively unusual in the neonates, are associated with substantial morbidity and mortality. Although S.pneumoniae has more than 90 serotypes, invasive disease is more common with certain serotypes. Pneumococcal polysaccharide and conjugate vaccines are developed against the serotypes that cause invasive disease. Until now invasive pneumococcal diseases have been defined due to various serotypes in the neonatal period. Here we present a neonate with an invasive pneumococcal disease due to S.pneumoniae serotype 7F which has not yet been reported in the literature. A 3180 g infant was born to a healthy 31 year old primigravida by normal vaginal delivery at 39 weeks gestation. Since the infant developed uneasiness, decreased sucking reflex and respiratory difficulty at postnatal 10th hour, he was admitted to the neonatal intensive care unit. Upon admission to intensive care unit mechanical ventilation, fluid replacement and empirical penicillin G and netilmycin had been initiated since the patient had hypotension, hypothermia and tachycardia. The infant later developed severe metabolic acidosis and had anemia, leukocytosis and high CRP values. CSF culture revealed no bacterial growth, however, S.pneumoniae was grown in the blood culture. The isolate was identified as serotype 7F by capsule swelling reaction. The vaginal specimen taken from the mother for the determination of the infectious foci revealed no pathogen growth. The patient's general condition improved after the second day of supportive treatment and antibiotherapy. Since the isolate was penicillin susceptible, the treatment continued with penicillin G and netilmycin for 14 days and the case was discharged with cure. This case was presented to emphasize that S.pneumoniae serotype 7F might lead to invasive disease not only during childhood but also during early neonatal period.

show abstract

Streptococcus pneumoniae invasive disease in the neonatal period: An increasing problem?

Abstract: S. pneumoniae should be specifically sought in swabs taken from the pregnant mother and newborn and if isolated, even in the absence of symptoms, antibiotic therapy against the organism should be strongly considered.

Cited by 25 publications

References 5 publications

PCR for the detection of pathogens in neonatal early onset sepsis

PCR for the detection of pathogens in neonatal early onset sepsis

Invasive Pneumococcal Disease Among Infants Before and After Introduction of Pneumococcal Conjugate Vaccine

An Early Neonatal Sepsis Case Due to Streptococcus pneumoniae Serotype 7F

Contact Info

Product

Resources

About