Streptococcal Bacteriostatic Antibody in Patients Treated with Penicillin.

Daikos, G. K.; Weinstein, Louis

doi:10.3181/00379727-78-19007

Cited by 50 publications

(14 citation statements)

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“…First, like M1 antibodies [17], M57, M12 and M55 antibodies may preferentially decline over time relative to CRS/DRS antibodies. Second, because M proteins are surface-bound, early treatment with antibiotics may remove the antigen along with the pathogen and suppress the type-specific antibody response [24], whereas CRS and DRS are secretory products, which may continue to circulate even after the disappearance of infecting GAS.…”

Section: Resultsmentioning

confidence: 99%

Antibodies to streptococcal inhibitor of complement function and M peptides in a post-streptococcal glomerulonephritis endemic region of Australia.

Sriprakash

Hartas

White

2002

Journal of Medical Microbiology

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Post-streptococcal glomerulonephritis (PSGN) is an immune-mediated disease in which an immune complex containing a streptococcal antigen are deposited in affected glomeruli. Strains of only some M types are known to be associated with PSGN. A secretory protein called SIC inhibits complement function. Whereas all M1 and M57 strains express closely related SIC (CRS), all M12 and M55 strains express distantly related SIC (DRS) proteins. Strains belonging to these four M types are historically associated with PSGN. This study used ELISA to analyse 112 sera from individuals with a recorded history of PSGN and 86 sera from individuals who had no such recorded history, all from a PSGN endemic region in tropical Australia. Antibody reactions to CRS, DRS and peptides corresponding to the N-termini of M1, M5, M12, M49, M55 and M57 antigens were assessed. A large proportion of the population showed reactions to each of these antigens and there was no correlation between CRS seropositivity and antibodies to CRS-positive M types. Likewise there was no correlation between DRS seropositivity and antibodies to DRS-positive M types. Interestingly, in this community endemic for PSGN a significantly higher proportion of DRS seropositive subjects had a recorded history of PSGN than did DRS seronegative subjects. DRS may have a predictive value for PSGN diagnosis or a role in PSGN pathogenesis.

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Section: Resultsmentioning

confidence: 99%

Antibodies to streptococcal inhibitor of complement function and M peptides in a post-streptococcal glomerulonephritis endemic region of Australia.

Sriprakash

Hartas

White

2002

Journal of Medical Microbiology

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“…First, as noted, antibiotic treatment of early infection is effective in preventing rheumatic illness (Denny et al, 1950). Second, early antibiotic therapy inhibits the development of the anti-M protein antibody responses implicated in pathogenesis (Daikos and Weinstein, 1951;Denny et al, 1957;Siegel et al, 1961). Finally, therapeutic failures ± rheumatic fever that occurs after appropriate antibiotic therapy of the pharyngeal infection ± are associated with persistent throat colonization with GAS (Catanzaro et al, 1958).…”

Section: Introductionmentioning

confidence: 99%

Bacterial determinants of persistent throat colonization and the associated immune response in a primate model of human group A streptococcal pharyngeal infection

Ashbaugh

Moser²,

Shearer³

et al. 2000

Cell Microbiol

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“…--1. General considerations: This test is essentially the same as that developed by Todd in 1927 for studying the bactericidal effect of the blood of patients on the homologous hemolytic streptococcus (16). More recently several investigators have used this test, slightly modified, for studies of the type-specific antibody response of patients following infection with group A streptococci (4,5,7,(17)(18)(19). Lyons and Ward also suggested in early studies the use of a similar test, based on the opsonic index, for type classification of group A streptococci, but they were unable to overcome the difficulties connected with the test (7).…”

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confidence: 99%

Differentiation of Group a Streptococci With a Common R Antigen Into Three Serological Types, With Special Reference to the Bactericidal Test

Lancefield

1957

The Journal of Experimental Medicine

267

231

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The classification of group A streptococci into types depends upon specific proteins, the M antigens, characteristic for each type. These M antigens are associated with virulence, and streptococci which contain them give rise to antibodies which promote phagocytosis of streptococci of homologous type and lead to type-specific protection of infected animals. Anti-M antibodies are demonstrable by M-precipitin reactions, bactericidal tests, and active and passive protection tests in mice (1-8).In studying the M proteins, it was found that the protein antigen which served to identify strains designated by Griifith as type 28 differed from the type-specific antigens of all other types in that it was not inactivated by trypsin and several other proteolytic enzymes (9). Pepsin was the only enzyme found which destroyed this antigen. Further studies showed that strains containing this antigen did not represent a single type, and that the antibody which had been used as the basis for their classification into one type did not protect mice against infection with these strains. Since this trypsin-resistant protein, now designated as R antigen, lacked one of the most characteristic properties of type-specific M antigens, namely, the ability to stimulate protective antibodies, it was obviously not the type-specific substance. Additional investigation of these strains was therefore undertaken (10).Initial attempts to classify two of these R-containing strains yielded inconclusive results: mouse protection and precipitin tests for M antibody in antiserum prepared against each were not definitive but suggested that, although partial cross-protection occurred, one strain might belong to type 2 and the other to type 13.In order to clarify these relationships it was thought possible that bactericidal tests might reveal specific M antibodies more readily than the tests used previously. The bactericidal method depends upon the phagocytosis and destruction of streptococci by human leukocytes in the presence of M antibody. The results obtained have the same significance with regard to immunity as those 525 on

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Streptococcal Bacteriostatic Antibody in Patients Treated with Penicillin.

Cited by 50 publications

References 0 publications

Antibodies to streptococcal inhibitor of complement function and M peptides in a post-streptococcal glomerulonephritis endemic region of Australia.

Antibodies to streptococcal inhibitor of complement function and M peptides in a post-streptococcal glomerulonephritis endemic region of Australia.

Bacterial determinants of persistent throat colonization and the associated immune response in a primate model of human group A streptococcal pharyngeal infection

Differentiation of Group a Streptococci With a Common R Antigen Into Three Serological Types, With Special Reference to the Bactericidal Test

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