Strategy of Patient-Specific Therapeutics in Cardiovascular Disease Through Single-Cell RNA Sequencing

Abstract

Author's summary This paper explained the concept of single cell sequencing and summarized how single cell sequencing can be used in cardiovascular research. The overall workflow of single cell sequencing was explained with a figure and the characteristics and limitations of single cell sequencing were described. After that, we showed the meaningful studies found through single cell sequencing in cardiovascular development. Finally, we described how the single cell sequencing technology is being used in clinical fields and precision medicine these days.

A new "single" era of biomedicine and implications in disease research

“…These independent or combined "single" technologies have helped us not only to create a high-resolution SC type map of human tissues [127] and three-dimensional nuclear architecture, gene expression, and epigenetic modifications, [128] but also to assess and analyze immune cell differentiation, [129,130] to uncover cellular and molecular mechanisms and to discover new therapeutic targets for human diseases, [49,[131][132][133] in particular COVID-19 and CVDs, as well as to trace cancer progression. [134] It can be said that this is indeed a new "single" era of biomedicine and its current implications and research in both CVDs and COVID-19 [135][136][137][138][139][140][141][142][143][144][145][146][147][148][149][150] as well as others will definitely open a new beautiful future.…”