Strategies to Increase the Production of Biosynthetic Riboflavin

Zhao, Gui‐Ling; Dong, Fanyi; Lao, Xingzhen; Zheng, Heng

doi:10.1007/s12033-021-00318-7

Cited by 19 publications

(8 citation statements)

References 71 publications

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“…ribCF and ribU are located in a separate genomic locus with respect to the operon, as described in Bifidobacterium longum by Solopova et al ( 30 ). The complete set of riboflavin biosynthetic genes was retrieved only in P. fabalis LMG 26217 T , P. fabaria LMG 24289 T , and P. ghanensis DSM 19935 T ; this finding suggests their putative capability of producing these compounds and of being used as biofortification agents, exploiting the possibility to increase the riboflavin biosynthesis through fermentative processes ( 31 ). All strains with the exception of W. diestrammenae DSM 27940 T and P. beninensis LMG 25373 T harbored the folP and folK genes, encoding the dihydropteroate synthase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, respectively; both genes are involved in folate (vitamin B 9 ) synthesis ( 19 ), leading to the hypothesis that these strains may exert the probiotic function of accomplishing folate biosynthesis in vivo within the colon, allowing treatment or prevention of low-folate conditions.…”

Section: Discussionmentioning

confidence: 99%

Probiotic Potential and Safety Assessment of Type Strains of Weissella and Periweissella Species

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Probiotic Potential and Safety Assessment of Type Strains of Weissella and Periweissella Species

et al. 2023

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“…Vitamin B 2 deficiency has an impact on iron absorption, the metabolism of tryptophan, mitochondrial dysfunction, the gastrointestinal tract, and brain dysfunction [ 21 ]. Regarding oral-related disorders, vitamin B 2 deficiency is associated with stomatitis, perleche, glossitis, and seborrheic dermatitis, resolving with correction of hypo nutrition of vitamin B 2 [ 22 ]. A recent study demonstrated that a lower serum level of vitamin B 2 increased the risk of radiation-induced mucositis among nasopharyngeal carcinoma patients who underwent radiotherapy [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Dietary Intake of Vitamins and Oral Health Behaviors: A Cross-Sectional Study

Ariizumi

Izumi

Akifusa

2023

IJERPH

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This study aimed to investigate whether oral health behaviors were related to the dietary intake of vitamins. In this cross-sectional study, we included respondents of the 2016 national health and nutrition examination survey, and dental diseases from Hyogo Prefecture, Japan. Data on sociodemographic characteristics, findings of blood tests related to metabolic syndrome, dietary intake, oral health status, and behaviors were collected. Participants were divided into two groups based on their oral health behavior: the yes group (performed interdental cleaning or tongue brushing) and the no group (did not perform the behaviors). The study included 218 participants (male: 107, female: 111) aged 64.5 (range, 22–93) years. There were 133 (61.0%) and 85 (39.0%) participants in the yes and no groups, respectively. The daily intake of vitamins A, B2, B6, E, and K, folic acid, and niacin in the yes group was significantly higher than that in the no group. Oral health behavior correlated with the intake of vitamin B2 (p = 0.029), folic acid (p = 0.006), and vitamin K (p = 0.043) after adjusting for possible confounders. Oral health behavior (interdental cleaning or tongue brushing) correlated with the daily intake of vitamins B2, K, and folic acid.

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“…We found that the coding genes of FXN and BLVRA were involved in controlling the growth and division of F. luteovirens under strong UV radiation, and regulated its yellow color at the later growth stage of F. luteovirens ( Figure 4A ). FMN and FAD, the main riboflavin derivatives, were cofactors of enzymes that mediated many redox reactions in cells, and riboflavin operon ribA gene encoded GTP, which was the first step of riboflavin biosynthesis ( Cisternas et al, 2017 ; Liu et al, 2020 ; Zhao G. et al, 2021 ). Accordingly, we found that F. luteovirens may have the capability of de novo riboflavin biosynthesis, and the ribA and ribH genes were directly involved in riboflavin synthesis.…”

Section: Discussionmentioning

confidence: 99%

The Molecular Mechanism of Yellow Mushroom (Floccularia luteovirens) Response to Strong Ultraviolet Radiation on the Qinghai-Tibet Plateau

Guo

Xie²,

Jiang³

et al. 2022

Front. Microbiol.

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The Qinghai-Tibet Plateau (QTP) is the highest plateau in the world, and its ultraviolet (UV) radiation is much greater than that of other regions in the world. Yellow mushroom (Floccularia luteovirens) is a unique and widely distributed edible fungus on the QTP. However, the molecular mechanism of F. luteovirens’s response to strong UV radiation remains unclear. Herein, we reported the 205 environmental adaptation and information processing genes from genome of F. luteovirens. In addition, we assembled the RNA sequence of UV-affected F. luteovirens at different growth stages. The results showed that in response to strong UV radiation, a total of 11,871 significantly different genes were identified, of which 4,444 genes in the vegetative mycelium (VM) stage were significantly different from the young fruiting bodies (YFB) stage, and only 2,431 genes in the YFB stage were significantly different from fruiting bodies (FB) stage. A total of 225 differentially expressed genes (DEGs) were found to be involved in environmental signal transduction, biochemical reaction preparation and stress response pathway, pigment metabolism pathway, and growth cycle regulation, so as to sense UV radiation, promote repair damage, regulate intracellular homeostasis, and reduce oxidative damage of UV radiation. On the basis of these results, a molecular regulation model was proposed for the response of F. luteovirens to strong UV radiation. These results revealed the molecular mechanism of adaptation of F. luteovirens adapting to strong UV radiation, and provided novel insights into mechanisms of fungi adapting to extreme environmental conditions on the QTP; the production the riboflavin pigment of the endemic fungi (Yellow mushroom) in the QTP was one of the response to extreme environment of the strong UV radiation.

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Strategies to Increase the Production of Biosynthetic Riboflavin

Cited by 19 publications

References 71 publications

Probiotic Potential and Safety Assessment of Type Strains of Weissella and Periweissella Species

Probiotic Potential and Safety Assessment of Type Strains of Weissella and Periweissella Species

Correlation between Dietary Intake of Vitamins and Oral Health Behaviors: A Cross-Sectional Study

The Molecular Mechanism of Yellow Mushroom (Floccularia luteovirens) Response to Strong Ultraviolet Radiation on the Qinghai-Tibet Plateau

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