Strategies for the design of bright upconversion nanoparticles for bioanalytical applications

Wiesholler, Lisa M.; Hirsch, Thomas

doi:10.1016/j.optmat.2018.04.015

Cited by 22 publications

(17 citation statements)

References 132 publications

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“…54 As strategies to enhance the brightness of UCNPs improve, their use as probes in biosensing and other applications will increase. 55 With the adaptability of the surface chemistry of UCNPs, 56 the method introduced here can be extended to a wide range of pHsensitive molecules with exquisite sensitivity. These quantitative titration measurements were performed using a simple spectrometer without a photomultiplier tube.…”

Section: Discussionmentioning

confidence: 99%

Upconversion nanoparticles for sensing pH

Tsai

Himmelstoß

Wiesholler

et al. 2019

Analyst

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Section: Discussionmentioning

confidence: 99%

Upconversion nanoparticles for sensing pH

Tsai

Himmelstoß

Wiesholler

et al. 2019

Analyst

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“…4,5 An intensive standing EM wave can be formed around the plasmonic nanostructure. [17][18][19][20][21][22] Plasmonic nanostructure arrays that are coupled to a metallic back reflecting film on a substrate are expected to exhibit substantially greater EM enhancement compared with plasmonic nanostructure arrays without back reflectors. [17][18][19][20][21][22] Plasmonic nanostructure arrays that are coupled to a metallic back reflecting film on a substrate are expected to exhibit substantially greater EM enhancement compared with plasmonic nanostructure arrays without back reflectors.…”

Section: Introductionmentioning

confidence: 99%

“…An intensive standing EM wave can be formed around the plasmonic nanostructure. Plasmon‐mediated nanostructures which periodically arranged onto the substrate have the potential to be utilized for a wide range of applications that involve maneuvering the EM spectrum such as light absorbers, photovoltaics, biochemical sensors, metamaterials, nano‐optical devices, surface‐enhanced Raman scattering, and upconversion luminescence . Plasmonic nanostructure arrays that are coupled to a metallic back reflecting film on a substrate are expected to exhibit substantially greater EM enhancement compared with plasmonic nanostructure arrays without back reflectors .…”

Section: Introductionmentioning

confidence: 99%

Light Absorption Enhancement by Employing A Plasmonic Nanobox Cavity Array

Jung

2019

Bulletin Korean Chem Soc

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This research numerically investigated a plasmonic nanobox cavity array situated on top of a back reflecting film to produce significant light confinement in close proximity to the nanobox configuration. The back reflector-coupled metallic nanostructure platform effectively absorbs incident light sources of a wide range of wavelengths due to local field enhancement from the coupling of the surface plasmon. The electromagnetic field distribution and light absorption spectra of the nanobox cavity platform were analyzed via a finite-difference time-domain method to identify the degree of absorption enhancement of the platform. By adjusting the design parameters of the nanostructure array, the absorption spectra peaks of the nanobox cavity platform can be precisely tuned. The proposed metallic nanostructure-based platform can be employed for various applications to achieve highly enhanced optical performance such as photovoltaics, surface-enhanced Raman scattering, and bio-sensing devices.

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“…[12,13] Many applications require strong upconversion to achieve high signal intensities and to keep the amount of nanoparticles in the organism low, which is why the high efficiency of the upconversion process is probably the most important issue when UCNPs are designed for biological applications. [14,15] Several strategies such as energy harvesting, plasmonic enhancement, or triplet excited states in order to improve the upconversion efficiency were already discussed in the literature. [16][17][18][19][20][21][22][23] One essential strategy is the protection of the lanthanide ions from the environment by passivating the nanoparticle surface with a non-doped NaYF 4 shell.…”

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confidence: 99%

Upconversion Nanocrystals with High Lanthanide Content: Luminescence Loss by Energy Migration versus Luminescence Enhancement by Increased NIR Absorption

Schroter

Märkl

Weitzel

et al. 2022

Adv Funct Materials

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Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted a lot of interest due to their benefits in biological applications: They are not suffering from intermittence and provide nearly background-free luminescence. The progress in synthesis nowadays enables access to complex core-shell particles of controlled size and composition. Nevertheless, the frequently used doping ratio dates back to where mostly core-only particles of relatively large size have been studied. Especially at low power excitation as needed in biology, a decrease in particle size leads to a drastic decrease in the upconversion efficiency. An enhancement strategy based on an increased absorption rate of near-infrared light provided by an increase of the sensitizer content, together with the simultaneous blocking of the energy migration pathways to the particle surface, is presented. NaYbF 4 (20%Er) particles of 8.5 nm diameter equipped with an about 2 nm thick NaYF 4 shell show significantly enhanced upconversion luminescence in the red (660 nm) compared to the most commonly used particles with only 20% Yb 3+ and 2% Er 3+ . The impact of size, composition, and core-shell architecture on photophysical properties are studied. The findings demonstrate that an increase in doping rates enables the design of small, bright UCNPs useful for biological applications.

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Strategies for the design of bright upconversion nanoparticles for bioanalytical applications

Cited by 22 publications

References 132 publications

Upconversion nanoparticles for sensing pH

Upconversion nanoparticles for sensing pH

Light Absorption Enhancement by Employing A Plasmonic Nanobox Cavity Array

Upconversion Nanocrystals with High Lanthanide Content: Luminescence Loss by Energy Migration versus Luminescence Enhancement by Increased NIR Absorption

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