Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.01.050 View full text
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Qiqing Zhong, Kenley K. Ngim, Megan Sun, Jane Li, Alan Deese, Nik P. Chetwyn

Abstract: Pinacolboronate esters (or boronic acid, pinacol esters) are widely used in the Suzuki coupling reaction to connect organic building blocks for the total synthesis of complex molecules. The 2-aminopyrimidine-5-pinacolboronate ester was used as a starting material in the synthesis of a development compound, necessitating a chromatographic purity method to assess its quality. This aryl pinacolboronate ester posed unique analytical challenges due to its facile hydrolysis to the corresponding boronic acid, which i…

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