Strategies and delivery systems for cell-based therapy in autoimmunity
Matteo Puccetti,
Claudio Costantini,
Aurélie Schoubben
et al.
Abstract:This review article explores the potential of engineering antigen-presenting cells (APCs) for the immunotherapy of autoimmune diseases. It discusses various strategies for modifying APCs to induce antigen-specific tolerance, thereby mitigating autoimmune responses. The review covers recent advancements in APC engineering techniques, including genetic modification and nanoparticle-based approaches, and evaluates their efficacy in preclinical models and clinical trials. Additionally, challenges and future direct… Show more
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