volume 6, issue 12, P1033-1048 2014
DOI: 10.18632/aging.100707
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Andrii I. Rozhok, Jennifer L. Salstrom, James DeGregori

Abstract: Age-dependent tissue decline and increased cancer incidence are widely accepted to be rate-limited by the accumulation of somatic mutations over time. Current models of carcinogenesis are dominated by the assumption that oncogenic mutations have defined advantageous fitness effects on recipient stem and progenitor cells, promoting and rate-limiting somatic evolution. However, this assumption is markedly discrepant with evolutionary theory, whereby fitness is a dynamic property of a phenotype imposed upon and w…

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