2015
DOI: 10.18632/aging.100792
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Abstract: In this study we applied a new analytical strategy to investigate the relations between stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through the Infinium HumanMethylation27 and HumanMethylation450 BeadChips in a population of 178 subjects ranging from 3 to 106 years. For each CpG probe, epimutated subjects were identified as the extreme outliers with methylation level exceeding three times interquartile ranges the first quartile (Q1-(3 × IQR)) or the third quartile (Q3+(3 × … Show more

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Cited by 58 publications
(92 citation statements)
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References 40 publications
(37 reference statements)
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“…cis-methylation quantitative loci (cis-meQTLs). In the remaining 370,234 CpGs, the number of epigenetic mutations ranged from 58 to 26,291 in each sample, using the definition in Gentilini et al [7]. Across samples, the number of epigenetic mutations had a right-skewed distribution, which was close to normal distribution after log10-transformation (Figure S1).…”
Section: Resultsmentioning
confidence: 91%
“…cis-methylation quantitative loci (cis-meQTLs). In the remaining 370,234 CpGs, the number of epigenetic mutations ranged from 58 to 26,291 in each sample, using the definition in Gentilini et al [7]. Across samples, the number of epigenetic mutations had a right-skewed distribution, which was close to normal distribution after log10-transformation (Figure S1).…”
Section: Resultsmentioning
confidence: 91%
“…In addition, we found mixed evidence regarding the association of DNA methylation outlier burden and lifestyle variables. DNA methylation outlier burden has previously been linked to smoking [19] but not to BMI [12,19]. In Generation Scotland, higher DNA methylation outlier burden was found to be significantly positively associated with smoking pack-years and significantly negatively associated with BMI.…”
Section: Dna Methylation Outlier Burden Health and Survivalmentioning
confidence: 86%
“…Here, we provide a comprehensive characterisation of DNA methylation outlier burden in three large independent cohorts. The sample size of the Generation Scotland cohort is an order of magnitude greater than previous studies [12][13][14]. In addition, this is the first study to systematically relate DNA methylation outlier burden to a range of diseases and to survival.…”
Section: Strengths and Limitationsmentioning
confidence: 98%
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