Davide Gentilini, Paolo Garagnani, Serena Pisoni, Maria Giulia Bacalini, Luciano Calzari, Daniela Mari, Giovanni Vitale, Claudio Franceschi, Anna Maria Di Blasio
Abstract:In this study we applied a new analytical strategy to investigate the relations between stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through the Infinium HumanMethylation27 and HumanMethylation450 BeadChips in a population of 178 subjects ranging from 3 to 106 years. For each CpG probe, epimutated subjects were identified as the extreme outliers with methylation level exceeding three times interquartile ranges the first quartile (Q1-(3 × IQR)) or the third quartile (Q3+(3 × …
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