STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy
Bandarigoda N. Somatilaka,
Laasya Madana,
Ali Sadek
et al.
Abstract:Neurofibromatosis type 1 (NF1) is caused by mutations in the
NF1
gene that encodes neurofibromin, a RAS GTPase–activating protein. Inactivating
NF1
mutations cause hyperactivation of RAS-mediated signaling, resulting in the development of multiple neoplasms, including malignant peripheral nerve sheath tumors (MPNSTs). MPNSTs are an aggressive tumor and the main cause of mortality in patients with NF1. MPNSTs are difficult to resect and refractory to chemo- and radi… Show more
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