Stimulus properties of venlafaxine in a conditioned taste aversion procedure

Kayır, Hakan; Alici, Tevfik; Göktalay, Gökhan; Yıldırım, Murat; Ulusoy, Kemal Gokhan; Ceyhan, Mustafa Nuri; Çelik, Turgay; Uzbay, Tayfun

doi:10.1016/j.ejphar.2008.08.015

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…As noted above, drug preexposure has been reported to attenuate the acquisition of taste avoidance, and the two drugs examined here have been used in such designs and have been shown to impact avoidance induced by other drugs (fluoxetine) and are impacted by drug history (MDMA). For example, fluoxetine preexposure attenuates avoidance induced by a variety of drugs including LiCl (Lorden & Nunn, 1982), MK212, 8-OH-DPAT and 2,5-dimethoxy-4-iodoamphetamine (Berendsen & Broekkamp, 1994), mirtazapine (Berendsen & Broekkamp, 1997), fluvoxamine (Gommans et al, 1998; see Olivier et al, 1999 for partial attenuation), cocaine (Jones et al, 2009; though see Serafine & Riley, 2013), and venlafaxine (Kayir et al, 2008). Further, MDMA-induced taste avoidance can be attenuated by prior exposure to MDMA.…”

Section: Discussionmentioning

confidence: 99%

“…Fluoxetine hydrochloride (Sigma) was dissolved in distilled water at a concentration of 5 mg/ml and injected subcutaneously (SC) at 10 mg/kg. This dose was selected based on research reporting that preexposure of fluoxetine at 10 mg/kg is effective in attenuating taste avoidance induced by a variety of other drugs (see Berendsen & Broekkamp, 1994; Kayir et al, 2008; Lorden & Nunn, 1982). MDMA (3, 4-MDMA hydrochloride, generously provided by the National Institute on Drug Abuse [NIDA] drug supply program) was dissolved in isotonic saline (0.9%) at a concentration of 2 mg/ml and injected SC at a dose of 3.2 mg/kg.…”

Section: Methodsmentioning

confidence: 99%

“…Interestingly, both fluoxetine and MDMA induce significant taste avoidance (fluoxetine: Ervin et al, 1995; Serafine & Riley, 2010; MDMA: Brox & Ellenbroek, 2018; Cobuzzi et al, 2014; Lin et al, 1993, 1994). Further, exposure to fluoxetine has been reported to attenuate avoidance induced by other drugs (LiCl: Lorden & Nunn, 1982; venlafaxine: Kayir et al, 2008; 6-Chloro-2-(1-piperazinyl) pyrazine and (±)-8-hydroxy-2-(di-n-propylamino)tetralin: Berendsen & Broekkamp, 1994), and MDMA-induced taste avoidance is attenuated by its own preexposure (Albaugh et al, 2011). No studies, however, have assessed the effects of fluoxetine history on MDMA-induced taste avoidance.…”

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confidence: 99%

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Impact of fluoxetine preexposure on MDMA-induced taste avoidance in male and female rats.

Bowman¹,

Huang²,

Vasquez³

et al. 2023

Experimental and Clinical Psychopharmacology

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The use of both prescription and illicit drugs creates the potential for drug interactions as a function of both pharmacokinetic and pharmacodynamic processes. One such interaction is that of fluoxetine and methylenedioxymethamphetamine (MDMA) in which fluoxetine attenuates the positive-like effects of MDMA. The present work extends the analysis of their interaction by examining the impact of fluoxetine on the aversive effects of MDMA which in balance with its rewarding effects may mediate its abuse potential. Male and female Sprague–Dawley rats were given fluoxetine (10 mg/kg every 4th day for five injections) prior to taste avoidance training with MDMA (3.2 mg/kg). MDMA induced taste avoidance in males and females (faster acquisition in females). Fluoxetine preexposure attenuated this avoidance in males, but not females. For males, the attenuation was partial as MDMA-conditioned animals with fluoxetine preexposure still displayed a significant reduction in fluid intake compared to controls. Consistent with prior work assessing the interaction of fluoxetine and MDMA, fluoxetine preexposure impacted the ability of MDMA to support taste avoidance learning, specifically attenuating the aversive effect of the drug. Prior work has shown that fluoxetine attenuates MDMA’s positive effects which might lead to reduced intake of the drug; however, the concurrent reduction in the drug’s aversive effects may still shift the overall affective balance of these two affective properties toward continued use and abuse. The fact that the attenuation was only evident in males needs further study to investigate the sex-dependent effects of drug history.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of fluoxetine preexposure on MDMA-induced taste avoidance in male and female rats.

Bowman¹,

Huang²,

Vasquez³

et al. 2023

Experimental and Clinical Psychopharmacology

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show abstract

“…Given that these compounds (ipsapirone, buspirone, RU-24969, sertraline, d-amphetamine, LSD, metergoline and idazoxane) were effective in blocking 8-OHDPAT-induced CTAs, De Beun and colleagues concluded that cross-drug preexposure could be used to assess the commonalities in aversion-inducing mechanism between different compounds (De Beun et al, 1993). Since this demonstration, several other investigations have also utilized this procedure to examine common mechanisms in the aversive effects of various compounds (see De Beun et al, 1996; Gommans et al, 1998; Jones et al, 2009; Kayir et al, 2008; Olivier et al, 1999; Van Hest et al, 1992; Serafine and Riley, 2009; 2010). …”

Section: Introductionmentioning

confidence: 99%

Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909

Serafine

Briscione

Rice

et al. 2012

Pharmacology Biochemistry and Behavior

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Although cocaine readily induces taste aversions, little is known about the mechanisms underlying this effect. It has been suggested that its inhibitory effects at one of the monoamine transporters may be mediating this suppression. Using the cross-drug preexposure preparation, the present series of studies examined a possible role of dopamine (DA) in this effect. Male Sprague-Dawley rats were exposed to cocaine (18 mg/kg; Experiment 1) or the selective DA transporter (DAT) inhibitor GBR 12909 (50 mg/kg; Experiment 2) prior to the pairing of a novel saccharin solution with injections of GBR 12909 (32 mg/kg), cocaine (18 mg/kg) or vehicle in a conditioned taste aversion (CTA) procedure. Preexposure to cocaine attenuated aversions induced by itself but not aversions induced by GBR 12909 (Experiment 1). Conversely, preexposure to GBR 12909 attenuated aversions induced by itself and cocaine (Experiment 2). This asymmetry suggests that cocaine and GBR 12909 induce CTAs via similar, but non-identical, mechanisms. These data are discussed in the context of previous work demonstrating roles for dopamine, norepinephrine and serotonin in cocaine-induced CTAs.

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The Discriminative Stimulus Properties of Drugs Used to Treat Depression and Anxiety

Prus

Porter

2016

The Behavioral Neuroscience of Drug Discrimination

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Drug discrimination is a powerful tool for evaluating the stimulus effects of psychoactive drugs and for linking these effects to pharmacological mechanisms. This chapter reviews the primary findings from drug discrimination studies of antidepressant and anxiolytic drugs, including novel pharmacological mechanisms. The stimulus properties revealed from these animal studies largely correspond to the receptor affinities of antidepressant and anxiolytic drugs, indicating that subjective effects may correspond to either therapeutic or side effects of these medications. We discuss drug discrimination findings concerning adjunctive medications and novel pharmacologic strategies in antidepressant and anxiolytic research. Future directions for drug discrimination work include an urgent need to explore the subjective effects of medications in animal models, to better understand shifts in stimulus sensitivity during prolonged treatments, and to further characterize stimulus effects in female subjects. We conclude that drug discrimination is an informative preclinical procedure that reveals the interoceptive effects of pharmacological mechanisms as they relate to behaviors that are not captured in other preclinical models.

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Stimulus properties of venlafaxine in a conditioned taste aversion procedure

Cited by 6 publications

References 30 publications

Impact of fluoxetine preexposure on MDMA-induced taste avoidance in male and female rats.

Impact of fluoxetine preexposure on MDMA-induced taste avoidance in male and female rats.

Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909

The Discriminative Stimulus Properties of Drugs Used to Treat Depression and Anxiety

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