Stimuli-responsive switchable MRI nanoprobe for tumor theranostics

Zheng, Min; Liu, Liuhui; Yue, Renye; Dong, Zhe; Lu, Chang; Zhang, Cheng; Guan, Guoqiang; Liu, Huiyi; Zhang, Qingpeng; Song, Guosheng

doi:10.1016/j.nantod.2023.101931

Cited by 21 publications

(9 citation statements)

References 142 publications

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“…Physiological microenvironments with acidic conditions can serve as valuable biomarkers for various diseases, offering dual functionality as both treatment targets and diagnostic indicators. 69 pH-Responsive drug delivery systems have emerged as a prominent modality in various medical domains, such as cancer diagnosis and treatment, 70 diabetes therapy, 71 skin disease therapy, 72 and anti-bacterial applications. 73 Peptide-loading PNCs formed with biodynamers offered enhanced efficacy and reduced systemic toxicity, attributable to their high drug LC% and controlled-release capabilities triggered by changes in pH.…”

Section: Resultsmentioning

confidence: 99%

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Liu,

Hamm,

Eichinger

et al. 2024

IJN

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Background Therapeutic proteins and peptides offer great advantages compared to traditional synthetic molecular drugs. However, stable protein loading and precise control of protein release pose significant challenges due to the extensive range of physicochemical properties inherent to proteins. The development of a comprehensive protein delivery strategy becomes imperative accounting for the diverse nature of therapeutic proteins. Methods Biodynamers are amphiphilic proteoid dynamic polymers consisting of amino acid derivatives connected through pH-responsive dynamic covalent chemistry. Taking advantage of the amphiphilic nature of the biodynamers, PNCs and DEs were possible to be prepared and investigated to compare the delivery efficiency in drug loading, stability, and cell uptake. Results As a result, the optimized PNCs showed 3-fold encapsulation (<90%) and 5-fold loading capacity (30%) compared to DE-NPs. PNCs enhanced the delivery efficiency into the cells but aggregated easily on the cell membrane due to the limited stability. Although DE-NPs were limited in loading capacity compared to PNCs, they exhibit superior adaptability in stability and capacity for delivering a wider range of proteins compared to PNCs. Conclusion Our study highlights the potential of formulating both PNCs and DE-NPs using the same biodynamers, providing a comparative view on protein delivery efficacy using formulation methods.

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Section: Resultsmentioning

confidence: 99%

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Liu,

Hamm,

Eichinger

et al. 2024

IJN

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“…In addition to the internal stimuli-responsive nanomedicines, external stimuli-responsive nanoparticles have been widely developed for nanotheranostics over the last decades. − In the early phase of development, sensitizers that could be activated with an external energy source, including light, US, and radio, were demonstrated; PDT, PTT, SDT, and radiodynamic therapy (RDT) were estimated using these sensitizers. Recently, growing interest in immunotherapy has led to a focus on ICD through DAMPs and pathogen-associated molecular patterns (PAMPs), which are byproducts of PDT, PTT, SDT, and RDT.…”

Section: Stimuli-responsive Polymeric Nanomedicine For Cancer Immunot...mentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Kim,

Lee,

et al. 2024

Chem. Mater.

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Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as a promising approach for counteracting the evasive tactics of cancer cells. This study delves into the innovative realm of stimuli-responsive polymeric nanomedicines in the context of cancer immunotherapy. By capitalizing on the intricate landscape of the tumor microenvironment (TME), which orchestrates immune suppression and tumor progression, stimuli-responsive nanomedicines offer a tailored strategy to enhance therapeutic interventions. The aberrant features of the TME, which include factors such as low pH, inflammation, oxidative stress, and enzyme overexpression, serve as triggers for intelligent delivery systems facilitated by functional polymers. This dynamic approach has the potential to overcome the challenges faced by traditional nanoparticle-based immunotherapy techniques, presenting a platform to precisely optimize drug delivery within the tumor locale. As the synergistic interaction between stimuli-responsive polymeric nanomedicines and the TME unfolds, a novel horizon emerges to advance the efficacy of cancer immunotherapy while mitigating its associated limitations.

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“…The use of MR imaging is favored as a diagnostic tool due to its exceptional ability to provide high-quality contrast between different soft tissues and its capability for unlimited penetration depth (Chen et al, 2023;C. Huang, Tsai, et al, 2011).…”

Section: Functional Engineeringmentioning

confidence: 99%

“…The use of MR imaging is favored as a diagnostic tool due to its exceptional ability to provide high‐quality contrast between different soft tissues and its capability for unlimited penetration depth (Chen et al, 2023; C. Huang, Tsai, et al, 2011). MR imaging techniques utilize a combination of radiofrequency waves, powerful magnets, and advanced computer algorithms to effectively distinguish between healthy and diseased tissues.…”

Section: Functional Engineeringmentioning

confidence: 99%

Engineering of copper sulfide mediated by phototherapy performance

Wu,

Huang,

Sha

et al. 2023

WIREs Nanomed Nanobiotechnol

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Copper sulfide based phototherapy, including photothermal therapy and photodynamic therapy, is an emerging minimally invasive treatment of tumor, which the light was converted to heat or reactive oxygen to kill the tumor cells. Compared with conventional chemotherapy and radiation therapy, Cu2−xS based phototherapy is more efficient and has fewer side effects. However, considering the dose‐dependent toxicity of Cu2−xS, the performance of Cu2−xS based phototherapy still cannot meet the requirement of the clinical application to now. To overcome this limitation, engineering of Cu2−xS to improve the phototherapy performance by increasing light absorption has attracted extensive attention. For better guidance of Cu2−xS engineering, we outline the currently engineering method being explored, including (1) structural engineering, (2) compositional engineering, (3) functional engineering, and (4) performance engineering. Also, the relationship between the engineering method and phototherapy performance was discussed in this review. In addition, the further development of Cu2−xS based phototherapy is prospected, including smart materials based phototherapy, phototherapy induced immune microenvironment modulation et al. This review will provide new ideas and opportunities for engineering of Cu2−xS with better phototherapy performance.This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Stimuli-responsive switchable MRI nanoprobe for tumor theranostics

Cited by 21 publications

References 142 publications

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Engineering of copper sulfide mediated by phototherapy performance

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