Stimuli-responsive polymersomes of poly [2-(dimethylamino) ethyl methacrylate]-b-polystyrene

Souza, Valdomiro Vagner de; Carretero, Gustavo; Vitale, Phelipe Augusto Mariano; Todeschini, Iris; Kotani, Paloma O.; Saraiva, Greice Kelle Viegas; Guzzo, Cristiane R.; Chaimovich, Hernán; Florenzano, Fabio Herbst; Cuccovia, Iolanda Midea

doi:10.1007/s00289-020-03533-5

Cited by 9 publications

(3 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the formation of nanosized aggregates appears to take place when poly(allylamine hydrochloride) (PAH) solutions is mixed with phosphate and polyphosphate anions. , As solution conformations of PAH change and nanoaggregates form even when adding monovalent H 2 PO 4 – , it seems likely that intermolecular forces other than electrostatic ones may play a role in driving the phenomenon. In particular, the formation of charged hydrogen bonds (c-H-bonds) between the ammonium cation and the phosphate anions may help explaining the described behavior as well as the unusually low “slip plane” potential measured for polymersomes with PDMAEMA arms in the presence of a phosphate buffer with pH ∼ 8 . The formation of c-H-bonds between poly(acrylic acid) and the sulfonate group in sulfobetaine tensides (i.e., surfactants), , or between ω-carboxylic and carboxylate groups in surfactants, − was also suggested to be involved in lowering the critical micelle concentration of the mentioned surfactants.…”

Section: Introductionmentioning

confidence: 92%

Impact of Chemically Specific Interactions between Anions and Weak Polyacids on Chain Ionization, Conformations, and Solution Energetics

Mella

Tagliabue

2022

Macromolecules

View full text Add to dashboard Cite

The presence of salts in a solution containing weak polyelectrolytes is known to modify both their titration behavior and conformations due to electrostatic screening. Instead, little is currently known about the changes induced by chemically specific interactions (e.g., charged hydrogen bonds, c-H-bonds). To investigate this aspect, we simulated the titration of weak polyacids with a primitive model and Monte Carlo methods in the presence of monovalent salts whose anions are capable of forming c-H-bonds with associated acid groups. The interaction between anions and weak polyacids (e.g., poly(acrylic acid)) substantially hampers ionization at low pH despite the somewhat limited number of coordinated anions, whereas it has a limited impact once pH > pK a + 2 due to a progressive anion decoordination. Importantly, the suppression of ionization appears extremely local in nature, with different chain segments differing in pK a by up to 1.3 units. As for chain conformations, c-H-bonds reduce the average sizes of polyacids independently of their structure as a consequence of multidentate binding or multiarm coordination in starlike species. Analyzing the length of chain segments with all monomers coordinated or uncoordinated has also evidenced that anion binding is extremely local in nature. The energetic analysis of c-H-bond formation suggests that polyacid chemical potential may be strongly lowered (up to −0.7 kcal/mol per monomer), the impact of such results on a few phenomena relevant for the physical chemistry of polyacid-containing solutions being analyzed in some detail.

show abstract

Section: Introductionmentioning

confidence: 92%

Impact of Chemically Specific Interactions between Anions and Weak Polyacids on Chain Ionization, Conformations, and Solution Energetics

Mella

Tagliabue

2022

Macromolecules

View full text Add to dashboard Cite

show abstract

“…Factors that control the morphology of vesicles include size, wall thickness (a function of the molecular weight of the constituent macromolecules), deformation (due to the pressure difference between the internal lumen and external medium of the vesicle during preparation), and surface topology (modification of the vesicle surface by inserting different compounds or combining vesicle-forming macromolecules) . The architecture of the copolymer can influence the morphology of self-assemblies, and the macromolecules that have been employed for vesicle formation have included block − and graft − copolymers, as well as branched polymers, in particular, miktoarm stars with asymmetric branching containing at least three polymeric arms. − …”

Section: Introductionmentioning

confidence: 99%

Polymersomes: Soft Nanoparticles from Miktoarm Stars for Applications in Drug Delivery

Baghbanbashi

Kakkar

2022

Mol. Pharmaceutics

View full text Add to dashboard Cite

Self-assembly of amphiphilic macromolecules has provided an advantageous platform to address significant issues in a variety of areas, including biology. Such soft nanoparticles with a hydrophobic core and hydrophilic corona, referred to as micelles, have been extensively investigated for delivering lipophilic therapeutics by physical encapsulation. Polymeric vesicles or polymersomes with similarities in morphology to liposomes continue to play an essential role in understanding the behavior of cell membranes and, in addition, have offered opportunities in designing smart nanoformulations. With the evolution in synthetic methodologies to macromolecular precursors, the construction of such assemblies can now be modulated to tailor their properties to match desired needs. This review brings into focus the current state-of-the-art in the design of polymersomes using amphiphilic miktoarm star polymers through a detailed analysis of the synthesis of miktoarm star polymers with tuned lengths of varied polymeric arms, their self-assembly, and applications in drug delivery.

show abstract

“…More than two decades ago, PDMAEMA and its copolymers were synthesized and evaluated as gene transfer agents and carrier systems for DNA [ 32 , 33 ]. Often, they are combined with petrochemical based polymers [ 34 ] or biobased polymers [ 35 , 36 ]. Water swelling tests on interpenetrating network (IPN) hydrogels based on nanofibrillated cellulose (NFC) and PDMAEMA prepared via crosslinking free radical polymerization showed that the IPN hydrogels were both pH-sensitive and temperature-sensitive.…”

Section: Introductionmentioning

confidence: 99%

Cellulose-g-poly(2-(dimethylamino)ethylmethacrylate) Hydrogels: Synthesis, Characterization, Antibacterial Testing and Polymer Electrolyte Application

Blažic

Grgić

Roković

et al. 2022

Gels

View full text Add to dashboard Cite

Hydrogels have been investigated due to their unique properties. These include high water content and biocompatibility. Here, hydrogels with different ratios of poly(2-(dimethylamino)ethylmethacrylate) (PDMAEMA) were grafted onto cellulose (Cel-g-PDMAEMA) by the free radical polymerization method and gamma-ray radiation was applied in order to increase crosslinking and content of PDMAEMA. Gamma irradiation enabled an increase of PDMAEMA content in hydrogels in case of higher ratio of 2-(dimethylamino)ethyl methacrylate in the initial reaction mixture. The swelling of synthesized hydrogels was monitored in dependence of pH (3, 5.5 and 10) during up to 60 days. The swelling increased from 270% to 900%. Testing of antimicrobial activity of selected hydrogel films showed weak inhibitory activity against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. The results obtained by the cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) indicate that chemically synthesized hydrogels have good characteristics for the supercapacitor application.

show abstract

Stimuli-responsive polymersomes of poly [2-(dimethylamino) ethyl methacrylate]-b-polystyrene

Cited by 9 publications

References 63 publications

Impact of Chemically Specific Interactions between Anions and Weak Polyacids on Chain Ionization, Conformations, and Solution Energetics

Impact of Chemically Specific Interactions between Anions and Weak Polyacids on Chain Ionization, Conformations, and Solution Energetics

Polymersomes: Soft Nanoparticles from Miktoarm Stars for Applications in Drug Delivery

Cellulose-g-poly(2-(dimethylamino)ethylmethacrylate) Hydrogels: Synthesis, Characterization, Antibacterial Testing and Polymer Electrolyte Application

Contact Info

Product

Resources

About