Stimuli-responsive nanocarriers for intracellular delivery

Tayo, Lemmuel L.

doi:10.1007/s12551-017-0341-z

Cited by 66 publications

(35 citation statements)

References 92 publications

(95 reference statements)

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“…At the current level of biotechnology, liposomes may be designed from basic blocks in laboratories and many components may be added inside and on their surface [41]. Liposomes can be used for diagnostic and therapeutic applications containing various markers or drugs [42,43]. Here, we assume that a layer of luciferase molecules is attached to each liposome.…”

Section: Example Of Medical Data Gathering Systemmentioning

confidence: 99%

Signal generation and storage in FRET-based nanocommunications

Kmiecik

Wójcik

Kułakowski

et al. 2019

Nano Communication Networks

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The paper is concerned with Fӧrster Resonance Energy Transfer (FRET) considered as a mechanism for communication between nanodevices. Two solved issues are reported in the paper, namely: signal generation and signal storage in FRET-based nanonetworks. First, luciferase molecules as FRET transmitters which are able to generate FRET signals themselves, taking energy from chemical reactions without any external light exposure, are proposed. Second, channelrhodopsins as FRET receivers, as they can convert FRET signals into voltage, are suggested. Further, medical in-body systems where both molecule types might be successfully applied, are discussed. Luciferasechannelrhodopsin communication is modeled and its performance is numerically validated, reporting on its throughput, bit error rate, propagation delay and energy consumption. IntroductionWith the current rapid development of technology, electronic and mechanical devices can be much smaller than even a decade ago, at the same time gaining new operating functionalities. However, when the device scale goes to the size of single molecules, cooperation between such devices and contacting them from outside their networks become quite challenging issues. Fӧrster Resonance Energy Transfer (FRET), a phenomenon characterized by very small propagation delays and a good throughput, has already been proposed for nanocommunications [1] and has been proved to be an efficient mechanism for transferring data at nanodistances [2][3][4]. Research on FRET for nanocommunication purposes and its integration with other elements on nanoworld is though at an early stage.The main contribution of the paper is solving two issues that, until now, were not solved for FRETbased communications [5]. The first issue is concerned with FRET signal storage. A molecule receiving a FRET signal cannot hold it and the signal must quickly be released, usually emitting a photon. Here, we propose to use channelrhodopsins which are molecules that can be used as nanoconverters, changing FRET signals into a voltage which can be detected by other devices. The second issue concerns FRET signal generation. In FRET nanocommunication experiments so far, a FRET transmission was initiated by an external laser source, which is rather troublesome inside a human body. Instead, we propose bioluminescent luciferase molecules as FRET transmitters, which are able to generate FRET signals themselves, taking energy from chemical reactions. We further discuss medical in-body systems where such FRET-based communication between luciferases and channelrhodopsins might be applied. We consider a system of small vesicles, liposomes, circulating through human vascular system and collecting data about body condition. The data gathered by liposomes are delivered to a detector placed in a human vein. Data transmission is realized by a luciferase-channelrhodopsin FRET interface. We model layers of luciferase and channelrhodopsin molecules based on their molecular structures and then we use their spectral characteristics to assess the e...

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Section: Example Of Medical Data Gathering Systemmentioning

confidence: 99%

Signal generation and storage in FRET-based nanocommunications

Kmiecik

Wójcik

Kułakowski

et al. 2019

Nano Communication Networks

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“…11). It is in honour of this service that we have contributions from a number of fellow APPA council members (North et al 2018;Tayo 2017;Sawitri et al 2018;Song 2018;Goto et al 2018).…”

Section: Scientific Process-societies and Servicementioning

confidence: 99%

“…The three Editors of this special issue would like to offer our sincere apologies to Assoc. Prof. Lemmuel Tayo of Mapua University (Philippines) whose article was accidentally included in the preceding issue of Biophysical Reviews (Tayo 2017). Through their long-term collaboration as fellow council members of the Asia Pacific Protein Association, Assoc.…”

Section: Compliance With Ethical Standardsmentioning

confidence: 99%

Foreword to ‘Multiscale structural biology: biophysical principles and mechanisms underlying the action of bio-nanomachines’, a special issue in Honour of Fumio Arisaka’s 70th birthday

2018

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This issue of Biophysical Reviews, titled 'Multiscale structural biology: biophysical principles and mechanisms underlying the action of bio-nanomachines', is a collection of articles dedicated in honour of Professor Fumio Arisaka's 70th birthday. Initially, working in the fields of haemocyanin and actin filament assembly, Fumio went on to publish important work on the elucidation of structural and functional aspects of T4 phage biology. As his career has transitioned levels of complexity from proteins (hemocyanin) to large protein complexes (actin) to even more massive bio-nanomachinery (phage), it is fitting that the subject of this special issue is similarly reflective of his multiscale approach to structural biology. This festschrift contains articles spanning biophysical structure and function from the bio-molecular through to the bio-nanomachine level.

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“…They may progress later to late endosomes and lysosomes. If the loading of dendrimer targets the nucleus, thus the nuclear membrane is another barrier that the dendrimer should come across [61].…”

Section: Dendrimers As Drug Delivery Systemsmentioning

confidence: 99%

Dendrimers as Drug Nanocarriers: The Future of Gene Therapy and Targeted Therapies in Cancer

Franiak-Pietryga¹,

Ziemba²,

Messmer³

et al. 2018

Dendrimers - Fundamentals and Applications

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Synthetic polymers, such as dendrimers, play a critical role in pharmaceutical discovery and development. Advances in the application of nanotechnology in medicine have given rise to multifunctional "smart" nanocarriers that can deliver one or more therapeutic agents safely and selectively to cancer cells, including intracellular gene-specific targeting. Dendrimers with their 3D nanopolymeric architectures are highly attractive class of drug and gene delivery vector. Advances in understanding and manipulating genes gave scientists a tool to make changes in people DNA to prevent or treat diseases. Over the past decade, gene therapy has been in use in clinical trials. The inactivation of the tumor suppressor genes is the main idea of the development of gene therapy in the cancer treatment. Broad spectrum of delivery concepts, including viral vectors, liposomes, cationic polymers and dendrimers, cell-penetrating peptides and gold and magnetic nanoparticles have been investigated. A well-designed vector is the most desirable approach to increase the safety of gene therapy, which is still in its infancy stages in cancer research. More experimental and clinical trials are focused on well-designed and effective doses of vectors that are essential for therapeutic efficacy of gene therapy for its potential in clinical use against a wide variety of cancers.

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Stimuli-responsive nanocarriers for intracellular delivery

Cited by 66 publications

References 92 publications

Signal generation and storage in FRET-based nanocommunications

Signal generation and storage in FRET-based nanocommunications

Foreword to ‘Multiscale structural biology: biophysical principles and mechanisms underlying the action of bio-nanomachines’, a special issue in Honour of Fumio Arisaka’s 70th birthday

Dendrimers as Drug Nanocarriers: The Future of Gene Therapy and Targeted Therapies in Cancer

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