1981
DOI: 10.1210/jcem-53-6-1297
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Abstract: The effects of vasoactive intestinal polypeptide (VIP), TRH, dopamine, and rat median eminence extract on GH release from GH-secreting pituitary adenomas were studied in vitro using a sensitive superfusion method. Dispersed pituitary tumor cells obtained from three patients with acromegaly were placed in a superfusion column, and the amounts of GH in the superfusate were determined. The addition of VIP (10(-6) M) to the perfusion system resulted in a marked increase in GH release in all three cases, and a dose… Show more

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Cited by 54 publications
(21 citation statements)
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“…Recently, vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM), both gastrointestinal hormones, have been reported to drive GH secretions in acromegalics in vitro [18][19][20] and in vivo [18,21] but not in normal subjects [18][19][20][21]. GIP as well as PHM is a member of the VIP Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM), both gastrointestinal hormones, have been reported to drive GH secretions in acromegalics in vitro [18][19][20] and in vivo [18,21] but not in normal subjects [18][19][20][21]. GIP as well as PHM is a member of the VIP Fig.…”
Section: Discussionmentioning
confidence: 99%
“…These observations raise intriguing questions concerning the functional interrelationship among the members of this peptide family. It has recently been reported that rat GRF is as potent as VIP in stimulating pancreatic amylase secre tion and that both peptides compete for the same receptor [10], In contrast, in the pituitary GRF does not stimulate Prl release [13] nor does VI Palter basal GH release under basal conditions [6], However, VIP antagonizes the inhibition of GH release by somatostatin [4] whereas in some acromegal ics the peptide induces a 'paradoxical' stimulation of GH release [8],…”
mentioning
confidence: 99%
“…They are referred to in passing when paradoxical hormone responses, such as an increase in GH secretion or intracellular Ca2+ concentration in somatotroph adenomas in response to TRH (Molitch, 1988), VIP (Kato et al, 1984;Matsushita et al, 1981), CRH (Ishibashi et al, 1984;Pieters et al, 1984), GnRH and vasopressin are mentioned, but the potential trophic implications are rarely addressed. This widespread expression of multiple and seemingly inappropriate hypothalamic hormone receptors (particularly TRH) in pituitary adenomas is further complicated by the identification of quite different responses to ligands in what appear to be adenomas of similar origin.…”
Section: Receptor Abnormalitiesmentioning
confidence: 99%