Biochemical Pharmacology volume 82, issue 7, P728-736 2011 DOI: 10.1016/j.bcp.2011.06.030 View full text
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Tomoaki Ishihara, Shintaro Suemasu, Teita Asano, Ken-ichiro Tanaka, Tohru Mizushima

Abstract: It is important in treatment of gastric ulcers to not only prevent further ulcer formation but also enhance ulcer healing. When cells are exposed to gastric irritants, expression of heat shock proteins (HSPs) is induced, making the cells resistant to the irritants. We recently reported direct evidence that HSPs, especially HSP70, are preventive against irritant-induced gastric ulcer formation. Gastric ulcer healing is a process involving cell proliferation and migration at the gastric ulcer margin and angiogen…

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