Stimulation of Cerebral Acetylcholinesterase Activity by Calcitonin: a Possible Mediation by 5-Hydroxytryptamine

Nakhla, Atif M.

doi:10.1159/000179117

Horm Res

1980

DOI: 10.1159/000179117

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Stimulation of Cerebral Acetylcholinesterase Activity by Calcitonin: a Possible Mediation by 5-Hydroxytryptamine

Atif M. Nakhla¹

Abstract: The stimulatory effect of calcitonin on cerebral acetylcholinesterase activity could not be observed in rats pretreated with p-chlorophenylalanine. The results suggest that the response of the enzyme activity to calcitonin is 5-hydroxytryptamine-mediated.

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1980

1993

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Cited by 6 publications

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“…Nevertheless, taken together, the obtained findings agree with the suggestion concern ing the involvement of brain serotonergic pathways in some central actions of calci tonins. In fact, it has been reported that a) the anorectic effect of sCT is strictly related to its ability to activate the serotonergic hypothalamic system (3), b) the analgesic activity of sCT involves a central serotonergic mechanism (9), and c) the stimulation of rat brain acetylcholinesterase activity induced by the porcine calcitonin is mediated by serotonin (10).…”

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confidence: 99%

Salmon calcitonin induced head twitch in the rat.

Gaggi

Iasio

1988

Jpn.J.Pharmacol

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Abstract-The intracerebroventricular administration of salmon calcitonin (sCT) to rats induced a dose-dependent increase in the number of head twitches and poten tiated such a response elicited by L-5-hydroxytryptophan (L-5-HTP). Subcu taneously administered sCT was ineffective "per se" but could again potentiate the head twitch response elicited by L-5-HTP.Since these data suggest a stimulation of the brain serotonergic pathways, the obtained results support the hypothesis that some central actions of sCT may involve activation of serotonergic systems in the rat brain.should enhance this increase. Head twitches were chosen as they are a quantifiable and reliable measure of serotonergic activation: the response is dose-related and appears even in the presence of low doses of 5-HT agonists (4). Male Sprague Dawley rats (Nossan, Milano, Italy) weighing 250-300 g were used. They were housed under con trolled conditions of light (7.00 a.m.-7.00 p.m.), temperature (22+2°C) and humidity (65%) and were allowed free access to standard laboratory diet and tap water. sCT was kindly supplied by Sandoz (Basel) as commercial vials (containing 100 MRCU=20 ug of peptide, 2 mg of acetic acid, 2 mg of sodium acetate, 7.5 mg of sodium chloride and distilled water to 1 ml volume) and as pure powder. As needed, these vials were diluted with saline, and sCT was s.c. injected at the doses of 5, 10, 20, 40 and 80 /ig/kg; control rats received 4 ml/kg of saline containing ace tic acid. I.c.v. injected rats were implanted, at least 7 days before the behavioral trials, with permanent plastic cannulae entering the right ventricle. By this route, the powder form of sCT dissolved in sterile saline containing 0.5% human albumin was administered at the doses of 0.1, 0.2, 0.4 and 0.8 ug/rat; control animals received only vehicle (20 al/rat). Immediately after treatment, the rats were put into transparent plexiglas cylinders (20 cm diameter, 25 cm height), and 30 min later, the head-twitches exhibited by the animals

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confidence: 99%

Salmon calcitonin induced head twitch in the rat.

Gaggi

Iasio

1988

Jpn.J.Pharmacol

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Localization of cholecystokinin-like and calcitonin-like peptides in infant carotid bodies: a light- and electron-microscopic immunohistochemical study

1993

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Previous immunohistochemical studies have identified several regulatory peptides in the carotid body chief cells in both humans and animals. These peptides, together with amines, may be important in the modulation of the chemoreflex by the carotid body. We report the localization and distribution of calcitonin and cholecystokinin-like (CCK) immunoreactivity in chief cells of human infant carotid body by light- and electron-microscopic immunohistochemical techniques. Consecutive sections immunostained with calcitonin and/or CCK antibodies revealed positively stained chief cells, both alone and in clusters, scattered throughout the carotid body lobule. Generally more chief cells were positive for calcitonin than for CCK. This was confirmed by quantitative analysis showing that the ratio of calcitonin to CCK immunoreactive cells was consistently > 2:1 in all cases studied. There was no apparent correlation between the immunoreactivity for the two peptides and the age, sex, or postmortem interval. Calcitonin-like and CCK-like immunoreactivities were localized electron-microscopically over the dense core granules of the chief cells. Calcitonin and CCK-like peptides in carotid body chief cells may act as neurotransmitters or neuromodulators involved in chemoreception.

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Effect of calcitonin on acetylcholinesterase activity in the gastrointestinal tract and pancreas

1980

J. Neural Transmission

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Stimulation of Cerebral Acetylcholinesterase Activity by Calcitonin: a Possible Mediation by 5-Hydroxytryptamine

Abstract: The stimulatory effect of calcitonin on cerebral acetylcholinesterase activity could not be observed in rats pretreated with p-chlorophenylalanine. The results suggest that the response of the enzyme activity to calcitonin is 5-hydroxytryptamine-mediated.

Cited by 6 publications

References 1 publication

Salmon calcitonin induced head twitch in the rat.

Salmon calcitonin induced head twitch in the rat.

Localization of cholecystokinin-like and calcitonin-like peptides in infant carotid bodies: a light- and electron-microscopic immunohistochemical study

Effect of calcitonin on acetylcholinesterase activity in the gastrointestinal tract and pancreas

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