volume 292, issue 2, PG492-G500 2007
DOI: 10.1152/ajpgi.00257.2006
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Abstract: Actions of adenosine 5Ј-monophosphate (AMP) on electrical and synaptic behavior of submucosal neurons in guinea pig small intestine were studied with "sharp" intracellular microelectrodes. Application of AMP (0.3-100 M) evoked slowly activating depolarizing responses associated with increased excitability in 80.5% of the neurons. The responses were concentration dependent with an EC50 of 3.5 Ϯ 0.5 M. They were abolished by the adenosine A2A receptor antagonist ZM-241385 but not by pyridoxal-phosphate-6-azophe…

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