Stilbenes from grapevine root: a promising natural insecticide against Leptinotarsa decemlineata

Gabaston, Julien; Khawand, Toni El; Waffo-Téguo, Pierre; Décendit, Alain; Richard, Tristan; Mérillon, Jean‐Michel; Pavela, Roman

doi:10.1007/s10340-018-0956-2

Cited by 40 publications

(22 citation statements)

References 36 publications

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“…Viticultural co‐products such as wood and roots are a source of bioactive stilbenes that may be used for several applications. Indeed, grapevine waste have a hopeful future of valorization in phytosanitary field as stilbenes have antifungal, oomycide and insecticide activities . In addition, grapevine extracts could be used for oenological purposes as alternative to SO 2 during the winemaking and also as toasted chips additive in order to produce wine with complex organoleptic properties .…”

Section: Resultscontrasting

confidence: 54%

“…Indeed, grapevine waste have a hopeful future of valorization in phytosanitary field as stilbenes have antifungal, oomycide and insecticide activities. 14,16,40 In addition, grapevine extracts could be used for oenological purposes as alternative to SO 2 during the winemaking and also as toasted chips additive in order to produce wine with complex organoleptic properties. 41,42 However, stilbene abundance could widely vary depending on the variety and rootstock, so there is a need to assess the stilbene composition of cultivars and rootstocks in order to determine the best sources.…”

Section: Stilbenes From Various Grapevine Cultivars and Rootstocksmentioning

confidence: 99%

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Wood and roots of major grapevine cultivars and rootstocks: A comparative analysis of stilbenes by UHPLC‐DAD‐MS/MS and NMR

Gabaston

Leborgne

Waffo-Téguo

et al. 2019

Phytochemical Analysis

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Introduction Grapevine wood and roots are by‐products obtained during vineyard management. This plentiful biomass is known to be rich in stilbenes and can be used as a source of high‐value compounds as well as active natural extracts. However, the stilbenes in grapevine wood and roots from different cultivars and rootstocks remain to be characterized. Objective The present study investigated the stilbene content of eight major Vitis vinifera cultivars and six different rootstocks. In addition, the distribution of stilbenes was established for each of seven parts into which the plants were sub‐divided. Methodology For stilbene characterization and quantification purposes, an ultra‐high performance liquid chromatography‐diode array detector‐mass spectrometry (UHPLC‐DAD‐MS/MS) analysis of different samples was carried out. Moreover, structural data of stilbenes was unambiguously studied by nuclear magnetic resonance (NMR) spectra. Results Whatever the cultivar/rootstock combination, stilbenes were found to be oligomerized from the aerial part to the root system. Furthermore, stilbene content varied widely depending on the cultivars and rootstocks. For instance, the cultivars Merlot, Tannat and Gamay noir were the richest in stilbenes while the rootstocks Gravesac, Fercal and 3390C contained the highest amounts. Conclusion These findings provide insight into the knowledge that major grapevine cultivars and rootstocks can be used as a potential source of complex stilbenes.

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Section: Resultscontrasting

confidence: 54%

Section: Stilbenes From Various Grapevine Cultivars and Rootstocksmentioning

confidence: 99%

Wood and roots of major grapevine cultivars and rootstocks: A comparative analysis of stilbenes by UHPLC‐DAD‐MS/MS and NMR

Gabaston

Leborgne

Waffo-Téguo

et al. 2019

Phytochemical Analysis

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“…Phytoseiid mites are valuable biological indicators and their presence indicates agro‐systems using less toxic pesticides . GCE also showed an absence of toxicity against soil macro‐organisms such as earthworms . Further studies are required to evaluate the impact of GCE on soil ecosystems.…”

Section: Resultsmentioning

confidence: 99%

Vineyard evaluation of stilbenoid‐rich grape cane extracts against downy mildew: a large‐scale study

Billet

Delanoue

Arnault

et al. 2018

Pest Management Science

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BACKGROUND: Plasmopara viticola control in organic viticulture requires copper-based fungicides with harmful effects on health and the environment. Plant extracts represent a biorational eco-friendly alternative to copper. The aim of this study was to evaluate the potential of stilbenoid-rich grape cane extract (GCE) against downy mildew on three cultivars over 3 years following natural downy mildew infection. RESULTS: Over all field trials, GCE treatments showed an average reduction in disease incidence of −35% and −38% on leaves and clusters, respectively. The average reduction in disease severity was −35% and −43% on leaves and clusters, respectively. Under artificial downy mildew infection, GCE efficacy corresponded to 1 g L −1 of copper. Neither phytotoxicity nor adverse effects on auxiliary fauna were observed after treatment with GCE. CONCLUSION: Because few or no biocontrol agents are active alone against P. viticola, GCE is a promising alternative to copper-based fungicides. Grape canes, an abundant by-product of viticulture, have great potential for valorization as a biocontrol agent for sustainable viticulture.

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“…The extract was kindly provided by Actichem S.A. (Montauban, France). The isolation, characterization and purification of the stilbenes were carried out as described previously [17]. The purity of the compounds was estimated to be ≥95%.…”

Section: Stilbenes From Vitis Viniferamentioning

confidence: 99%

Screening of Natural Stilbene Oligomers from Vitis vinifera for Anticancer Activity on Human Hepatocellular Carcinoma Cells

et al. 2020

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The characterization of bioactive resveratrol oligomers extracted from Vitis vinifera canes has been recently reported. Here, we screened six of these compounds (ampelopsin A, trans-ε-viniferin, hopeaphenol, isohopeaphenol, R2-viniferin, and R-viniferin) for their cytotoxic activity to human hepatocellular carcinoma (HCC) cell lines p53 wild-type HepG2 and p53-null Hep3B. The cytotoxic efficacy depended on the cell line. R2-viniferin was the most toxic stilbene in HepG2, with inhibitory concentration 50 (IC50) of 9.7 ± 0.4 µM at 72 h, 3-fold lower than for resveratrol, while Hep3B was less sensitive (IC50 of 47.8 ± 2.8 µM). By contrast, hopeaphenol (IC50 of 13.1 ± 4.1 µM) and isohopeaphenol (IC50 of 26.0 ± 3.0 µM) were more toxic to Hep3B. Due to these results, and because it did not exert a large cytotoxicity in HH4 non-transformed hepatocytes, R2-viniferin was selected to investigate its mechanism of action in HepG2. The stilbene tended to arrest cell cycle at G2/M, and it also increased intracellular reactive oxygen species (ROS), caspase 3 activity, and the ratio of Bax/Bcl-2 proteins, indicative of apoptosis. The distinctive toxicity of R2-viniferin on HepG2 encourages research into the underlying mechanism to develop the oligostilbene as a therapeutic agent against HCC with a particular genetic background.

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Stilbenes from grapevine root: a promising natural insecticide against Leptinotarsa decemlineata

Cited by 40 publications

References 36 publications

Wood and roots of major grapevine cultivars and rootstocks: A comparative analysis of stilbenes by UHPLC‐DAD‐MS/MS and NMR

Wood and roots of major grapevine cultivars and rootstocks: A comparative analysis of stilbenes by UHPLC‐DAD‐MS/MS and NMR

Vineyard evaluation of stilbenoid‐rich grape cane extracts against downy mildew: a large‐scale study

Screening of Natural Stilbene Oligomers from Vitis vinifera for Anticancer Activity on Human Hepatocellular Carcinoma Cells

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