Stiffness Indexes β of the Common Carotid and Femoral Arteries Are Associated With Insulin Resistance in NIDDM

Emoto, Masanori; Nishizawà, Yoshiki; Kawagishi, Takahiko; Maekawa, Kiyoshi; Hiura, Yoshikazu; Kanda, Hiroyuki; Izumotani, Kyoko; Shoji, Tetsuo; Ishimura, Eiji; Inaba, Masaaki; Okuno, Yasuhisa; Morii, Hirotoshi

doi:10.2337/diacare.21.7.1178

Cited by 146 publications

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“…7 Increased aortic PWV has been described by both Wahlqvist 26 and Lehman 27 in otherwise healthy subjects with type 2 diabetes. Salomaa 28 and Emoto 29 have also reported increased carotid artery stiffness in this patient group. Furthermore, in the ARIC study, carotid artery stiffness was positively correlated with serum glucose concentration.…”

Section: Arterial Stiffness and Type 2 Diabetes Mellitussupporting

confidence: 63%

Arterial stiffness, hypertension and diabetes mellitus

2000

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Section: Arterial Stiffness and Type 2 Diabetes Mellitussupporting

confidence: 63%

Arterial stiffness, hypertension and diabetes mellitus

2000

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“…In a study of 41 subjects a correlation between fasting glucose levels and local aortic distensibility was shown using a local invasive method 21 . In addition, one study using echo-tracking found an association between insulin resistance and femoral and carotid stiffness in patients with diabetes mellitus 22 . The proposed mechanisms of how 8 diabetes results in arterial stiffness are numerous and include for example formation of AGEproducts, as well as the influence of oxidative stress, monocyte vascular adhesion and inflammation on the arterial wall 23 .…”

Section: Discussionmentioning

confidence: 99%

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

2014

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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Link to publication Citation for published version (APA): Gottsäter, M., Länne, T., & Nilsson, P. M. (2014). Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Journal of Human Hypertension, 28(7), 456-460. DOI: 10.1038456-460. DOI: 10. /jhh.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractArterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment -insulin resistance (HOMA-IR), lipids and abdominal obesity.This study includes 335 subjects from Malmö, Sweden, examined in 1991 and again at follow-up in 1998-2000. Ultrasound measurement of the abdominal aorta was performed at follow-up investigation.In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (beta=0.18, p=0.03) and a negative association between high density lipoprotein and aortic stiffness (beta=-0.23, p=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.

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“…Although arterial stiffness has been examined in populations at increased risk for cardiovascular disease, including diabetes mellitus, 6 hypertension, 7 and postmenopausal women, 8 there are limited data exploring the hemodynamic characteristics of, specifically, premenopausal women and their risk for cardiovascular disease. Prior studies have examined the association of obesity and arterial stiffness in populations that included women from adolescence to older age.…”

Section: Introductionmentioning

confidence: 99%

Central aortic pulsatile hemodynamics in obese premenopausal women

Ounis–Skali

Bentley‐Lewis

Mitchell

et al. 2007

Journal of the American Society of Hypertension

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Obesity is a known risk factor for cardiovascular disease (CVD) but the mechanism by which obesity contributes to cardiovascular risk is not well understood. Arterial stiffness is a CVD risk factor associated with obesity. We studied 16 obese body mass index (BMI > 30) and 10 lean (BMI < 25) healthy premenopausal women. We measured fasting glucose, insulin, and lipids, blood pressure, and arterial tonometry to assess arterial stiffness. Obese women had higher glucose, insulin, total cholesterol and triglyceride levels, blood pressures, cardiac output, and peak flow. Characteristic impedance was lower (146 ± 31 [(dyne · s) · cm −5 ] vs. 187 ± 48 [(dyne · s) · cm −5 ]; P = .01), aortic diameter was greater (2.54 ± 0.20 cm vs. 2.29 ± 0.21 cm; P < .01), and peripheral pulse pressure was similar in obese compared with lean women. Obesity in premenopausal women is associated with increased cardiac output and peak aortic flow. Increased aortic diameter in obese women was associated with reduced characteristic impedance, potentially preventing an increase in peripheral pulse pressure despite elevated flow, which suggests proximal aortic remodeling. When aortic remodeling and compensation for increased hemodynamic demands are limited by environmental or genetic interference, hypertension or CVD may result.

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Stiffness Indexes β of the Common Carotid and Femoral Arteries Are Associated With Insulin Resistance in NIDDM

Abstract: Arterial stiffness indexes beta of CCA and FA were associated with insulin resistance in NIDDM subjects.

Cited by 146 publications

References 0 publications

Arterial stiffness, hypertension and diabetes mellitus

Arterial stiffness, hypertension and diabetes mellitus

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Central aortic pulsatile hemodynamics in obese premenopausal women

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