Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome

Rojas, Edward; Bermúdez, Valmore; Motlaghzadeh, Yasaman; Mathew, Justin; Fidilio, Enzamaría; Faría, José; Rojas, Joselyn; Bravo, Mayela Cabrera de; Contreras, Julio; Mantilla, Linda Pamela; Angarita, Lissé; Sepúlveda, Paola Amar; Kuzmar, Isaac

doi:10.1007/s13668-018-0228-z

Cited by 29 publications

(17 citation statements)

References 92 publications

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“…Studies have shown that compounds found in stevia are not teratogenic, mutagenic, or carcinogenic and cause no acute or subacute toxicity . Moreover, reports have been promising regarding the potential benefits of stevia against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension . Interestingly, based on the present data, it might be reasonable to postulate that stevia is a potential natural plant to treat patients with liver disorders.…”

Section: Discussionmentioning

confidence: 63%

Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways

Ramos‐Tovar

Buendia-Montaño

Galindo-Gómez

et al. 2018

Hepatology Research

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Aim The aims of the present study were to investigate the capacity of stevia leaves to prevent experimental cirrhosis induced by chronic administration of carbon tetrachloride (CCl4) in rats and to explore the action mechanism involved. Methods Liver cirrhosis was established by CCl4 treatment (400 mg/kg i.p. three times a week for 12 weeks); stevia powder was administered (100 mg/kg by gavage daily) during the CCl4 treatment. Serum markers of liver damage and hydroxyproline were evaluated and histopathological analyses were carried out. The profibrotic pathways were analyzed by western blot and immunohistochemistry. Results We found for the first time that stevia cotreatment prevented the elevation of serum markers of necrosis and cholestasis and the occurrence of liver fibrosis. It is worth noting that stevia downregulated several profibrogenic pathways, including the reduction of hepatic myofibroblasts and decreased matrix metalloproteinase (MMP)2 and MMP13 expression, thereby blocking the liberation of transforming growth factor‐β from the extracellular matrix. Notably, stevia reduced the phosphorylation of pSmad3L, the most profibrogenic and mitogenic Smad, by inhibiting the activation of c‐Jun N‐terminal kinase and extracellular signal‐regulated kinase. Interestingly, Smad7, an important antifibrotic molecule, was upregulated by stevia treatment in cirrhotic rats. These multitarget mechanisms led to the prevention of experimental cirrhosis. Conclusions Because stevia possesses a reasonable safety profile, our results indicate that it could be useful in the clinical setting to treat chronic liver diseases.

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Section: Discussionmentioning

confidence: 63%

Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways

Ramos‐Tovar

Buendia-Montaño

Galindo-Gómez

et al. 2018

Hepatology Research

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“…With increased consumer interest in reducing sugar intake, food products made with sweeteners rather than sugar have become more popular [42]. Additionally, consumption of stevia has demonstrated to be generally safe in most reports [43].…”

Section: Discussionmentioning

confidence: 99%

Contemporary Trends and Habits in the Consumption of Sugar and Sweeteners—A Questionnaire Survey among Poles

Pielak

Czarniecka-Skubina

Trafiałek

et al. 2019

IJERPH

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The purpose of the paper was a cross sectional study to evaluate the use of sugars and selected sweeteners by Polish consumers in their diet. The survey was conducted using the direct interview method on the group of 2000 adults declaring the consumption of sugar or sweeteners. The ANOVA test and multi-dimensional cluster analysis was used to the data interpretation (p < 0.05). It was stated that the consumption of sugar among consumers remained at a high level. Respondents declared taking up the activities towards reducing sugar intake in their diet mostly due to health-related reasons. It was emphasized in particular by women taking part in the survey. The most frequent way to limit the amount of sugar in the diet consisted in choosing sweeteners, mainly stevia and xylitol. However, the knowledge concerning steviol glycosides among the consumers was not extensive. Results are the source of up-to-date information concerning the consumption of sugar and sweeteners. Consumers to whom nutrition campaigns on the necessity to limit the content of sugar in the diet are worth addressing were identified. A hypothesis, that consumers are currently more aware of the negative influence of increased sugar consumption on their health and they aim at limiting the content of added sugar in their diet, was confirmed.

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“…The chemical structure of steviol glycoside present as an aglycone (steviol) and three molecules of glucose (Chatsudthipong and Muanprasat 2009). To date, at least 12 steviol glycosides have been identified from stevia leaves, which one of the best-known being stevioside (Rojas et al 2018). Other steviol glycosides are rebaudioside (A-F), steviolbioside and dulcoside A (Shibata et al 1995;Rojas et al 2018).…”

Section: Chemical Constituent and Extraction Of The Bioactive Compounmentioning

confidence: 99%

“…To date, at least 12 steviol glycosides have been identified from stevia leaves, which one of the best-known being stevioside (Rojas et al 2018). Other steviol glycosides are rebaudioside (A-F), steviolbioside and dulcoside A (Shibata et al 1995;Rojas et al 2018). As cultivation conditions may affect the content of glycosides in stevia leaves, the yield of steviosides and rebaudioside A can from 16.3-95 mg/g and 6.86-44.1 mg/g of dry leaves weight, respectively (Wood et al 1955).…”

Section: Chemical Constituent and Extraction Of The Bioactive Compounmentioning

confidence: 99%

‘Sweeter’ than its name: anti-inflammatory activities of Stevia rebaudiana

et al. 2020

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Inflammation plays a major role in etiology of multiple diseases and it has become an imperative therapeutic target in pharmacological interventions. Over the years, natural products originating from plants have made great contributions in the drug discovery process. Belonging to the Asteraceae family, Stevia rebaudiana (S. rebaudiana) is exploited at a large scale for its purpose as a natural sweetener. Even so, researchers have begun to notice other bioactive potential use of stevia such as anti-inflammatory and anti-cancer activities, which are conferred by compounds present in the leaves including stevioside, rebaudioside and isosteviol. In this review, we provide a brief overview of S. rebaudiana plant and its bioactive compounds and highlight their anti-inflammatory potential for therapeutic applications.

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Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome

Cited by 29 publications

References 92 publications

Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways

Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways

Contemporary Trends and Habits in the Consumption of Sugar and Sweeteners—A Questionnaire Survey among Poles

‘Sweeter’ than its name: anti-inflammatory activities of Stevia rebaudiana

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