Sterols from six marine sponges

Clionosterol and Ethyl Cholestan-22-enol Isolated from the Rhizome of <i>Polygala tenuifolia</i> Inhibit Phosphatidylinositol 3-Kinase/Akt Pathway

“…These isolated compounds were identified by instrumental analysis and compared to an authentic standard as reported in the literature. [14][15][16] Clionasterol (1) Live/Dead Assay of Tat-Expressing CHME5 Cell Line The previously established Tat-expressing CHME5 cells were used for this study. 5) Tat-expressing CHME5 cells were treated with 50 µg/mL LPS and 10 µg/mL CHX stress in the presence or absence of test agents.…”

Chemo-ecological studies on hexactinellid sponges from the Southern Ocean

“…In animal cellular membranes, cholesterol is predominant, but some sponges and holoturians, have unusual sterols. Biochemical coordination has been proposed to provide protection from own membranolitic toxins, with altered membrane steroid compositions correlated with defensive chemistry (Santalova et al 2004(Santalova et al , 2007. Actually, in many sponges, a symbiotic origin of unusual steroids and secondary metabolites is supported, while those containing conventionaltype sterols are often devoid of procariotic symbionts (Lawson et al 1988).…”

A-NOR STEROIDS FROM THE MARINE SPONGE, Clathria SPECIES

“…The genus Clathria from the family Microcionidae is classified as Demospongia and contains approximately 544 accepted species worldwide [5]. Of these, some species from the marine regions of Australia, Argentina, Indo-Pacific, Korea, Panama, Philippines and New Zealand have been phytochemically investigated and found to contain alkaloids [6][7][8][9][10][11][12], amides [13], peptides [14,15], anthraquinones [16], and terpenoids [17][18][19][20][21][22][23]. Meanwhile, biological activities including antibacterial [7,11,21,22], anti-HIV [18], cytotoxicity towards cancer cell lines [9,10,13,14,22], anti-inflammatory [19], and antiplasmodial [24] have been attributed to the species in the genus Clathria.…”