Steroids for Migraine Headaches: A Randomized Double-Blind, Two-Armed, Placebo-Controlled Trial

Fiesseler, Frederick; Shih, Richard D.; Szucs, Paul A.; Silverman, Michael E.; Eskin, Barnet; Clement, M.G.; Saxena, Richa; Allegra, J.R.; Riggs, Renee; Majlesi, Nima

doi:10.1016/j.jemermed.2009.08.022

Cited by 37 publications

(31 citation statements)

References 11 publications

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“…Similar results have been noted in adults with insignificant improvement in migraine recurrence 72 hours after discharge in adult patients who received dexamethasone as part of their migraine therapy . Additional studies have shown that the addition of dexamethasone to a variety of migraine treatment regimens failed to result in significant reductions in headache relapse at 48‐72 hours after discharge and that steroids do not prevent recurrence of migraine headaches in adult patients treated in the emergency department setting . However, meta‐analyses exploring the effectiveness of steroids in the treatment of acute migraine therapy in adults have shown that steroids can significantly reduce migraine recurrence .…”

Section: Discussionsupporting

confidence: 57%

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Factors Influencing Migraine Recurrence After Infusion and Inpatient Migraine Treatment in Children and Adolescents

et al. 2015

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Section: Discussionsupporting

confidence: 57%

“…Corticosteroids are often administered as an adjunct to treatment protocols due to the potential of reducing the recurrence of migraine headaches after discharge. Several studies done in adult patients have yielded conflicting results, with predominately moderate or statistically insignificant benefits …”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Migraine Recurrence After Infusion and Inpatient Migraine Treatment in Children and Adolescents

et al. 2015

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“…'s study but they did not perform subgroup analyses. Recently, another study that compared intravenous dexamethasone or oral prednisone with placebo failed to show a benefit of steroid treatment for recurrent migraine headaches .…”

Section: Discussionmentioning

confidence: 99%

“…However, this previous study mainly focused on intravenous dexamethasone. Recently, some studies on oral steroids for prevention of recurrent migraine have been reported .…”

Section: Introductionmentioning

confidence: 99%

“…However, this previous study mainly focused on intravenous dexamethasone. Recently, some studies on oral steroids for prevention of recurrent migraine have been reported [16,17]. Correspondence This study aimed to assess the evidence from RCTs on the effectiveness and tolerability of steroids for acute migraine headaches in adults and the prevention of recurrence of these headaches.…”

Section: Introductionmentioning

confidence: 99%

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Steroids for preventing recurrence of acute severe migraine headaches: a meta‐analysis

Huang

Cai

Song³

et al. 2013

Euro J of Neurology

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Headache in the first manifestation of Multiple Sclerosis – Prospective, multicenter study

et al. 2017

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ObjectivesMultiple sclerosis (MS) is the most frequent immune‐mediated inflammation of the central nervous system that can lead to early disability. Headaches have not been considered as MS‐related symptoms initially, whereas higher prevalence rates were reported since 2000. Postmortem histological analyses of MS patients’ brains revealed lymphoid follicle‐like structures in the cerebral meninges which suggest a possible pathophysiological explanation for the high headache prevalence in MS. The aim of this study was to evaluate headache characteristics during the first clinical event of MS.MethodsIn a prospective, multicenter study, 50 patients with the diagnosis of CIS or MS were recruited. All participants were screened for the presence of headache within the last 4 weeks with help of the Rostock Headache Questionnaire (Rokoko).ResultsThirty‐nine of fifty questioned patients (78%) reported headaches within the last 4 weeks. Most patients suffered from throbbing and pulsating headaches (25, 50%), 15 (30%) reported stabbing, 14 (28%) dull and constrictive headaches.ConclusionsHeadaches were prevalent in 78% of patients in our population with newly diagnosed CIS and MS. It is among the highest prevalence rates reported so far in patients with CIS or MS. Thus, headache, especially of a migraneous subtype, is a frequent symptom within the scope of the first manifestation of multiple sclerosis. If it were possible to define a MS‐typical headache, patients with these headaches and with typical MRI results would be classified as CIS or early MS instead of radiologically isolated syndrome and treated accordingly with an immunomodulatory therapy.

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Steroids for Migraine Headaches: A Randomized Double-Blind, Two-Armed, Placebo-Controlled Trial

Cited by 37 publications

References 11 publications

Factors Influencing Migraine Recurrence After Infusion and Inpatient Migraine Treatment in Children and Adolescents

Factors Influencing Migraine Recurrence After Infusion and Inpatient Migraine Treatment in Children and Adolescents

Steroids for preventing recurrence of acute severe migraine headaches: a meta‐analysis

Headache in the first manifestation of Multiple Sclerosis – Prospective, multicenter study

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