Steroidal saponins from Tribulus terrestris

Anti-hyperglycaemic Activity of <i>Tribulus terrestris</i> L Aerial Part Extract in Glucose-loaded Normal Rabbits

“…This observed potential anti-hyperglycaemic activity might be due to the large presence of saponins in T. terrestris [22]. Saponin from T. terrestris reported to possess hypoglycemic properties and produced protective effect in streptozotocin-induced diabetic rats by inhibiting oxidative stress [23].…”

“…Saponin from T. terrestris reported to possess hypoglycemic properties and produced protective effect in streptozotocin-induced diabetic rats by inhibiting oxidative stress [23]. Some of the main active compounds of T. terrestris identified and purified include: steroidal furostanol and spirostanol saponins -protodioscin, terrestrinins A and B, gitogenin, hecogenin, diosgenin and others [22]. The saponin characterized as tigogenin-…”

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.

“…In traditional Chinese and Indian medicine, the fruit is used in the treatment of infertility, impotence, erectile dysfunction and low libido (Gauthaman et al 2002;Gauthaman and Ganesan 2008;Singh and Gupta 2011). Phytochemical studies have shown the presence of several compounds in ethanolic, hexanic and methanolic extracts of T. terrestris such as steroidal saponins, flavonoids and alkaloids (Bedir and Khan 2000;Dinchev et al 2008;Su et al 2009). Some studies have assessed the effect of T. terrestris administration on male reproductive system and showed that the plant could positively influence on spermatogenesis (Bashir et al 2009;Elahi et al 2013;Keshtmand et al 2014).…”

Terrestrosin D, a Steroidal Saponin from <b><i>Tribulus terrestris</i></b> L., Inhibits Growth and Angiogenesis of Human Prostate Cancer in vitro and in vivo

“…Recent studies have shown that T. terrestris extracts induce cell growth arrest and apoptosis by downregulating NF-κB signaling in liver cancer cells, and that it exhibits weak cytotoxic effects to normal cells compared to cancer cells [9,10]. The observed biological activities of T. terrestris are mainly due to its abundant steroidal saponins [10,11,12,13]. Researchers have focused on steroidal saponins as potential candidates for the development of chemotherapeutic agents due to their anticancer effects [14,15,16].…”