Steroidal saponins from Fritillaria pallidiflora Schrenk

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

“…Other compounds with anticancer activity were chosen definitely less often and these include: actinomycin D, adriamycin, beta-L-(-)-dioxalane-cytidine (-)-OddC, camptothecin, elipticin, etoposide, 5-FU, mitamycin C, mitoxantrone, nimustine (ACNU), podophyllotoxin, staurosporine, tamoxifen, and troxacitabine. In one study resveratrol, which is not an approved anticancer drug, served as the control (Shen et al 2012).…”

Phytochemical and biological research of Fritillaria medicinal resources

“…Steroidal saponins consist of a steroidal aglycone, a C27 spirostane skeleton, generally comprising of a six-ring structure (Figure 4.3). Four saponins showed cytotoxicity against C6 and HeLa cell lines with IC 50 values 5.1-75.8 mM (Shen et al, 2012a). Four saponins showed cytotoxicity against C6 and HeLa cell lines with IC 50 values 5.1-75.8 mM (Shen et al, 2012a).…”

Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine

“…Further purification was performed using reverse phase (RP) preparative HPLC chromatography and other methods, and finally, sixteen saponins were isolated from SRS. On the basis of the analytical methods such as UV, IR, MS and extensive 1 H and 13 C NMR spectra analysis and comparison with data in literature (Huang et al, 2006;Kang et al, 2012;Li et al, 2006;Matsuda et al, 2003;Mimaki et al, 2000;Shao et al, 2007;Shen et al, 2012;Zhao et al, 2007), the sixteen saponins were identified as parisyunnanoside A, smilaxchinoside A, protogracillin, parisaponin I, parisyunnanoside C, pseudoproto-pb, riparoside B, parisyunnanoside E, parisyunnanoside D, smilaxchinoside C, paris H, timosaponin J, paris D, timosaponin K, parisvietnaside A and pallidfloside D. The structures of these sixteen saposins are shown in Fig. 1.…”