Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Tubeeckx, Michiel; Laga, Steven; Jacobs, Christel; Stroe, Marina; Cruchten, Steven Van; Goovaerts, Bo; fraeyenhove, Jens Van; Miljoen, Hielko; Meyer, Guido; Keulenaer, Gilles W. De; Heidbüchel, Hein; Segers, Vincent F.M.

doi:10.3791/63094-v

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study showed a model of sterile pericarditis-induced atrial myopathy in Aachen minipigs, suggesting a model of structural remodeling in AF. 12 The study demonstrated that atrial fibrosis resulting from the inflammation of the pericardium and myocardium preceded the induction of AF. In comparison with our study, the progressive increases in pacing thresholds over time are consistent.…”

Section: Swine Versus Canine Sterile Pericarditis Model For Studying ...mentioning

confidence: 95%

“…Recently, the swine has been increasingly used for cardiac research because it has similar physical and electrophysiological properties to humans, and is socially more accepted 10,11 . Although a recent study reported a model of sterile pericarditis‐induced atrial myopathy in Aachen minipigs, the study failed to induce POAF during postoperative period (within 5 days) after open heart surgery 12 . The purpose of this study is to validate the feasibility of the swine sterile pericarditis model as an experimental counterpart to study POAF.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Although a recent study reported a model of sterile pericarditis-induced atrial myopathy in Aachen minipigs, the study failed to induce POAF during postoperative period (within 5 days) after open heart surgery. 12 The purpose of this study is to validate the feasibility of the swine sterile pericarditis model as an experimental counterpart to study POAF. To do this, we compared the electrophysiologic data between the swine pericarditis model and previously published canine sterile pericarditis model for validation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Lee,

Khrestian,

Laurita

et al. 2023

Pacing Clinical Electrophis

View full text Add to dashboard Cite

BackgroundThe canine sterile pericarditis model associated with atrial inflammation is an experimental counterpart of postoperative atrial fibrillation (POAF). However, the use of canines for research is restricted by ethics committees in many countries, and social acceptance is declining.ObjectiveTo validate the feasibility of the swine sterile pericarditis model as an experimental counterpart to study POAF.MethodsSeven domestic pigs (35–60 kg) underwent initial pericarditis surgery. On two or more postoperative days in the closed‐chest state, we performed electrophysiological measurements of pacing threshold and atrial effective refractory period (AERP) while pacing from the right atrial appendage (RAA) and the posterior left atrium (PLA). The inducibility of POAF (>5 min) by burst pacing was determined in both the conscious and anesthetized closed‐chest state. These data were compared to previously published canine sterile pericarditis data for validation.ResultsThe pacing threshold increased from day 1 to day 3 (2 ± 0.1 to 3.3 ± 0.6 mA in the RAA, 2.5 ± 0.1 to 4.8 ± 0.2 mA in the PLA). Also, the AERP increased from day 1 to day 3 (118 ± 8 to 157 ± 16 ms in the RAA; 98 ± 4 to 124 ± 2 ms in the PLA, both p < .05). Induction of sustained POAF occurred in 43% (POAF CL range 74–124 ms). All electrophysiologic data from the swine model were consistent with the canine model with respect to (1) the range of both pacing threshold and AERP; (2) the progressive increase in threshold and AERP over time; (3) a 40%–50% incidence of POAF.ConclusionA newly developed swine sterile pericarditis model demonstrated electrophysiologic properties consistent with the canine model and patients after open heart surgery.

show abstract

Section: Swine Versus Canine Sterile Pericarditis Model For Studying ...mentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Lee,

Khrestian,

Laurita

et al. 2023

Pacing Clinical Electrophis

View full text Add to dashboard Cite

show abstract

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Abstract: We describe a sterile pericarditis model in minipigs for the study of atrial myopathy and atrial fibrillation (AF). We present surgical and anesthetic techniques, strategies for vascular access, and a protocol to study the inducibility of AF.

Cited by 1 publication

References 0 publications

Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Contact Info

Product

Resources

About