Stereotactic arrhythmia radioablation for refractory scar-related ventricular tachycardia

Gianni, Carola; Rivera, Douglas; Burkhardt, J. David; Pollard, Brad; Gardner, Edward A.; Maguire, Patrick; Zei, Paul C.; Natale, Andrea; Al‐Ahmad, Amin

doi:10.1016/j.hrthm.2020.02.036

Cited by 107 publications

(91 citation statements)

References 32 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study is registered in the ClinicalTrials.gov database of the On the other hand, in the study by Gianni et al [13], despite the favourable safety profile, the efficacy was suboptimal and longterm arrhythmia control was not achieved, similarly to the recently published retrospective case series by Chin et al [11].…”

Section: Trial Registrationmentioning

confidence: 95%

Stereotactic management of arrhythmia – radiosurgery in treatment of ventricular tachycardia (SMART-VT) – clinical trial protocol and study rationale

et al. 2021

View full text Add to dashboard Cite

Patients with vetricular tachycardia are usually treated with antiarrhythmic drugs and ablation if the arrhythmia substrate is available for invasive treatment. Despite high efficiency of this treatment there is a significant group of patients who do not benefit from available treatment methods, either because they cannot be applied or do not allow for durable control of the disease. For that reason a novel treatment method, STereotactic Arrhythmia Radioablation (STAR) has been proposed and its safety and efficiency is extensively studied throughout the world. The method is based on irradiation of the arrhythmia substrate identified with electrophysiological examination with high-precision image-guided radiosurgical methods usually used for ablation of malignant tumors. Here we present the protocol of the first Polish study on STAR in patients with intractable ventricular tachycardia (STARVT, NCT04642963), designed to test the safety of the method. Secondary endpoints include measures of the treatment efficiency.

show abstract

Section: Trial Registrationmentioning

confidence: 95%

Stereotactic management of arrhythmia – radiosurgery in treatment of ventricular tachycardia (SMART-VT) – clinical trial protocol and study rationale

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Recently, another prospective study published by Gianni et al (68) conducted on five patients mitigates these results. Indeed, the 1-year follow-up reports a recurrence of ventricular arrhythmias in all patients, despite an initial reduction observed in the first 6 months post-ablation.…”

Section: From Pre-clinical Data To First Patientsmentioning

confidence: 96%

Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions

Jumeau

Özşahin

Schwitter

et al. 2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Ventricular tachycardia (VT) caused by myocardial scaring bears a significant risk of mortality and morbidity. Antiarrhythmic drug therapy (AAD) and catheter ablation remain the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Stereotactic body radiotherapy (SBRT) is routinely used in oncology to treat non-invasively solid tumors with high precision and efficacy. Recently, this technology has been evaluated for the treatment of VT. This review presents the basic underlying principles, proof of concept, and main results of trials and case series that used SBRT for the treatment of VT refractory to AAD and catheter ablation.

show abstract

“…Not all centers report similarly positive results. In the study by Gianni et al for example, five patients underwent 25 Gy single fraction radioablation delivered by CyberKnife, and all patients experienced clinically significant mid-to lateterm ventricular arrhythmia recurrence (median follow-up of about 1 year) (36). In addition, to date, the ability for simultaneous gating of respiratory and cardiac movement is lacking.…”

Section: Stereotactic Radioablationmentioning

confidence: 99%

Future Perspectives and New “Frontiers” in Cardiac Rhythmology

Anselmino

Ferrari

2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Stereotactic arrhythmia radioablation for refractory scar-related ventricular tachycardia

Abstract: doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

Cited by 107 publications

References 32 publications

Stereotactic management of arrhythmia – radiosurgery in treatment of ventricular tachycardia (SMART-VT) – clinical trial protocol and study rationale

Stereotactic management of arrhythmia – radiosurgery in treatment of ventricular tachycardia (SMART-VT) – clinical trial protocol and study rationale

Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions

Future Perspectives and New “Frontiers” in Cardiac Rhythmology

Contact Info

Product

Resources

About