Stereologic Measurement of Cell Volume Fraction of Rabbit Corneal Stroma

A Role for Monosaccharides in Nucleation Inhibition and Transport of Collagen

“…As collagenous tissues transition from embryonic development to maturity, the tissue composition shifts dramatically from a predominantly cellular volume to a restrictively dense network of fibrillar arrays. [54][55][56][57][58][59][60][61] Priority is given to load-bearing structures, and ECM microenvironments of fiber bundles are established with the nearest cells often residing tens of microns away. Despite this restricted cellular access, the COL fibrils are still reliant on constant selfrepair.…”

A Role for Monosaccharides in Nucleation Inhibition and Transport of Collagen

“…As collagenous tissues transition from embryonic development to maturity, the tissue composition shifts dramatically from a predominantly cellular volume to a restrictively dense network of fibrillar arrays. [54][55][56][57][58][59][60][61] Priority is given to load-bearing structures, and ECM microenvironments of fiber bundles are established with the nearest cells often residing tens of microns away. Despite this restricted cellular access, the COL fibrils are still reliant on constant selfrepair.…”

Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

“…Corneal keratocytes are structurally flattened cells that account for 40% of the stroma volume in newborns, but only approximately 5% in the adult cornea 25 26 . Keratocytes interconnected through occasional desmosomal-like junctions have been studied by TEM and scanning electron microscopy 27 28 .…”

Magic Angle–Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading

“…On the other hand, there is a rich water content in the corneal stroma and to a lesser extent in the sclera. 46,47 The difference in tissue water composition might explain the lower background MR signal intensities and the smaller T2 and T2* values of the sclera relative to the cornea at all measured orientations throughout the study. The superficial layers of the corneal stroma contain more traversing fibers 48,49 and proteoglycans, which possess high water-binding capacity, 50 and possibly lower T2 and T2* than the deeper layers.…”

A Role for Monosaccharides in Nucleation Inhibition and Transport of Collagen

“…As collagenous tissues transition from embryonic development to maturity, the tissue composition shifts dramatically from a predominantly cellular volume to a restrictively dense network of fibrillar arrays. [54][55][56][57][58][59][60][61] Priority is given to load-bearing structures, and ECM microenvironments of fiber bundles are established with the nearest cells often residing tens of microns away. Despite this restricted cellular access, the COL fibrils are still reliant on constant selfrepair.…”

Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

“…Corneal keratocytes are structurally flattened cells that account for 40% of the stroma volume in newborns, but only approximately 5% in the adult cornea 25 26 . Keratocytes interconnected through occasional desmosomal-like junctions have been studied by TEM and scanning electron microscopy 27 28 .…”

Magic Angle–Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading

“…On the other hand, there is a rich water content in the corneal stroma and to a lesser extent in the sclera. 46,47 The difference in tissue water composition might explain the lower background MR signal intensities and the smaller T2 and T2* values of the sclera relative to the cornea at all measured orientations throughout the study. The superficial layers of the corneal stroma contain more traversing fibers 48,49 and proteoglycans, which possess high water-binding capacity, 50 and possibly lower T2 and T2* than the deeper layers.…”

A Role for Monosaccharides in Nucleation Inhibition and Transport of Collagen

“…As collagenous tissues transition from embryonic development to maturity, the tissue composition shifts dramatically from a predominantly cellular volume to a restrictively dense network of fibrillar arrays. [54][55][56][57][58][59][60][61] Priority is given to load-bearing structures, and ECM microenvironments of fiber bundles are established with the nearest cells often residing tens of microns away. Despite this restricted cellular access, the COL fibrils are still reliant on constant selfrepair.…”

Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

“…Corneal keratocytes are structurally flattened cells that account for 40% of the stroma volume in newborns, but only approximately 5% in the adult cornea 25 26 . Keratocytes interconnected through occasional desmosomal-like junctions have been studied by TEM and scanning electron microscopy 27 28 .…”

Magic Angle–Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading

“…On the other hand, there is a rich water content in the corneal stroma and to a lesser extent in the sclera. 46,47 The difference in tissue water composition might explain the lower background MR signal intensities and the smaller T2 and T2* values of the sclera relative to the cornea at all measured orientations throughout the study. The superficial layers of the corneal stroma contain more traversing fibers 48,49 and proteoglycans, which possess high water-binding capacity, 50 and possibly lower T2 and T2* than the deeper layers.…”