Stenotrophomonas maltophilia genomes: A start-up comparison

Rocco, Francesco; Gregorio, Eliana De; Colonna, Bianca; Nocera, Pier Paolo Di

doi:10.1016/j.ijmm.2009.05.004

Cited by 43 publications

(52 citation statements)

References 43 publications

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“…The stem sequences were complementary in most of the SMAGs within the subfamilies, suggesting that the secondary folding of the repeat sequences can occur at the DNA and RNA levels of organization. Gene transcription analyses of S. maltophilia genomes from strains K279A, STM2, 545, and 1029 have provided evidence to support the hypothesis that SMAG repeats influence mRNA stability (281). A comparison of the SMAG sequences in K279A with the genomes of environmental isolates S. maltophilia R551-3 and SKA14 revealed them to contain SMAG sequences of all 5 subfamilies but with different sizes of these subfamilies.…”

Section: Comparing Clinical and Environmental S Maltophilia Isolatesmentioning

confidence: 90%

“…The genome of clinical isolate S. maltophilia K279a contains gene clusters used for the import, storage, and efflux of metals (67). A comparison of clinical isolate K279a and environmental isolate R551-3 of S. maltophilia revealed that some metal resistance is common to both isolates and that some operons are found only in K279a (281).…”

Section: Resistance To Metalsmentioning

confidence: 99%

“…Sequencing data for S. maltophilia isolates K279a and R551-3 demonstrated the highly variable content of genomic islands (281). In K279a, 41 genomic islands (constituting 12.1% of the genome and 597 open reading frames [ORFs]) have been identified, with the majority being Ͼ15 kb in size, while R551-3 harbors 36 islands (constituting 6.6% of the genome and 249 open reading frames), and just four islands are Ͼ15 kb.…”

Section: Comparing Clinical and Environmental S Maltophilia Isolatesmentioning

confidence: 99%

“…The presence or absence of genomic islands is a major source of the heterogeneity observed between the two isolates. Genomic island gene products identified to have a role in interactions with the environment have included metal resistance genes, type I and IV secretion systems, LPS genes, and filamentous hemagglutinin genes (281). The two S. maltophilia isolates do not share common genomic islands but do contain genes with the same function.…”

Section: Comparing Clinical and Environmental S Maltophilia Isolatesmentioning

confidence: 99%

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Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia can occur in a range of organs and tissues; the organism is commonly found in respiratory tract infections. This review summarizes the current literature and presents S. maltophilia as an organism with various molecular mechanisms used for colonization and infection. S. maltophilia can be recovered from polymicrobial infections, most notably from the respiratory tract of cystic fibrosis patients, as a cocolonizer with Pseudomonas aeruginosa . Recent evidence of cell-cell communication between these pathogens has implications for the development of novel pharmacological therapies. Animal models of S. maltophilia infection have provided useful information about the type of host immune response induced by this opportunistic pathogen. Current and emerging treatments for patients infected with S. maltophilia are discussed.

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Section: Comparing Clinical and Environmental S Maltophilia Isolatesmentioning

confidence: 90%

Section: Resistance To Metalsmentioning

confidence: 99%

Section: Comparing Clinical and Environmental S Maltophilia Isolatesmentioning

confidence: 99%

Section: Comparing Clinical and Environmental S Maltophilia Isolatesmentioning

confidence: 99%

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Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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“…Only two of them were detected in other sequenced S. maltophilia strains (ISSmaD4 and Tn5044). Among the predicted coding sequences of D457, we found that more than 200 genes were not shared with the other strains of S. maltophilia with completely sequenced genomes (6,11,22). Notably, most of them encoded hypothetical proteins and transposases, which indicates that the core genome of S. maltophilia is large.…”

mentioning

confidence: 93%

Whole-Genome Sequence of Stenotrophomonas maltophilia D457, a Clinical Isolate and a Model Strain

et al. 2012

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Genetic Manipulation of Stenotrophomonas maltophilia

et al. 2015

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Stenotrophomonas maltophilia is a Gram‐negative, aerobic, motile, environmental bacterium that is emerging as an important nosocomial pathogen with high rates of attributable mortality in severely ill patients. S. maltophilia is of particular concern to patients suffering from cystic fibrosis (CF) as it has been shown to colonize airway epithelial and establish a chronic infection. Here we describe several molecular techniques for the genetic manipulation of this bacterium, including DNA extraction, RNA extraction, conjugation of plasmids from Escherichia coli and allelic exchange. © 2015 by John Wiley & Sons, Inc.

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Stenotrophomonas maltophilia genomes: A start-up comparison

Cited by 43 publications

References 43 publications

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

Whole-Genome Sequence of Stenotrophomonas maltophilia D457, a Clinical Isolate and a Model Strain

Genetic Manipulation of Stenotrophomonas maltophilia

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