Stem Cells Probed as Diabetes Treatment

In Vivo Imaging of β-Cell Mass in Rats Using 18F-FP-(+)-DTBZ: A Potential PET Ligand for Studying Diabetes Mellitus

“…These approaches focus mainly on preserving or replacing BCM and include pancreas or islet cell transplantation (4)(5)(6)(7)(8) or islet cell regeneration from stem cells. The ability to monitor BCM in vivo will facilitate development of disease-modifying therapies for diabetes mellitus (9)(10)(11). Indeed, in the past few years many attempts have been made to image BCM; most of this work has been based on specific binding sites or receptors, such as sulfonylurea receptors and other binding sites in the pancreas (12)(13)(14)(15).…”

In Vivo Imaging of β-Cell Mass in Rats Using 18F-FP-(+)-DTBZ: A Potential PET Ligand for Studying Diabetes Mellitus

“…These approaches focus mainly on preserving or replacing BCM and include pancreas or islet cell transplantation (4)(5)(6)(7)(8) or islet cell regeneration from stem cells. The ability to monitor BCM in vivo will facilitate development of disease-modifying therapies for diabetes mellitus (9)(10)(11). Indeed, in the past few years many attempts have been made to image BCM; most of this work has been based on specific binding sites or receptors, such as sulfonylurea receptors and other binding sites in the pancreas (12)(13)(14)(15).…”

In Vivo Imaging of β-Cell Mass in Rats Using 18F-FP-(+)-DTBZ: A Potential PET Ligand for Studying Diabetes Mellitus

“…These approaches focus mainly on preserving or replacing BCM and include pancreas or islet cell transplantation (4)(5)(6)(7)(8) or islet cell regeneration from stem cells. The ability to monitor BCM in vivo will facilitate development of disease-modifying therapies for diabetes mellitus (9)(10)(11). Indeed, in the past few years many attempts have been made to image BCM; most of this work has been based on specific binding sites or receptors, such as sulfonylurea receptors and other binding sites in the pancreas (12)(13)(14)(15).…”

In Vivo Imaging of β-Cell Mass in Rats Using 18F-FP-(+)-DTBZ: A Potential PET Ligand for Studying Diabetes Mellitus

“…These approaches focus mainly on preserving or replacing BCM and include pancreas or islet cell transplantation (4)(5)(6)(7)(8) or islet cell regeneration from stem cells. The ability to monitor BCM in vivo will facilitate development of disease-modifying therapies for diabetes mellitus (9)(10)(11). Indeed, in the past few years many attempts have been made to image BCM; most of this work has been based on specific binding sites or receptors, such as sulfonylurea receptors and other binding sites in the pancreas (12)(13)(14)(15).…”